{"hq_id":"hq-p-pet-000085","name":"Lily Ingestion and Feline Acute Renal Failure (Lilium and Hemerocallis Species — Easter, Tiger, Daylily, Asiatic — Unidentified Toxin, 100% Mortality Without Treatment)","category":{"primary":"pet","secondary":"plant_toxicity","tags":["lily","Lilium","Hemerocallis","Easter lily","tiger lily","daylily","Asiatic lily","feline acute renal failure","cat-specific","ASPCA APCC","100% mortality"]},"product_tier":"PET","overall_risk_level":"severe","description":"True lilies (genus Lilium) and daylilies (genus Hemerocallis) cause acute renal tubular necrosis in cats with mortality approaching 100% if treatment is not initiated within 18 hours of exposure. The toxic principle remains UNIDENTIFIED despite decades of investigation — multiple candidate fractions have been screened (steroidal glycoalkaloids, glycosaminoglycans) without definitive identification, which is why this product file references no specific compound hq_ids and the toxin(s) remain a Phase 56 SCI-14 enrichment candidate. ALL parts of the plant are toxic — petals, leaves, stamens, pollen, even the water from a vase containing lilies. As little as 2-3 leaves or one stamen ingestion causes acute renal tubular necrosis. ASPCA APCC ranks lily exposure in the top 10 feline plant-toxicity categories, with seasonal spikes around Easter (Lilium longiflorum, Easter lily) and Mother's Day (mixed-bouquet tiger and Asiatic lilies). Dogs are NOT affected by this specific renal toxicity (mild GI signs only) — the syndrome is feline-specific. Treatment requires aggressive intravenous fluid diuresis within 18 hours; delayed presentation yields anuric renal failure with mortality >90%. Prevention is absolute — keep all true lilies and daylilies out of cat households entirely; calla, peace, and peruvian lilies are botanically NOT in genus Lilium and do not cause this specific syndrome (though peace lily contains insoluble calcium oxalate crystals — a separate, milder oral irritation pattern).","synthesis":{"derived_risk_level":"insufficient_data","synthesis_confidence":0,"synthesis_method":"none","context_source":null,"compounds_resolved":0,"compounds_total":0,"synthesis_date":"2026-05-09","synthesis_version":"1.2.0","methodology_note":"exposure_modifier and adjusted_magnitude are computed from ALETHEIA-calibrated heuristics (route × duration × frequency multipliers, clamped to [0.5, 1.4]). Multipliers are directionally informed by EPA Exposure Factors Handbook (2011) and CalEPA OEHHA but are not regulatory consensus. See /api/methodology for full disclosure."},"hazard_summary":{"sensitive_populations":"ALL CATS — feline-specific toxicity; not species-stratified within Felidae","overall_risk":"severe","primary_concerns":["100% mortality without treatment; >90% mortality if delayed >18 hours","Toxic principle unidentified — no specific antidote","All plant parts toxic — petals, leaves, stamens, pollen, vase water","Cats can be exposed via grooming pollen from fur — no direct chewing required","Seasonal peak Easter / Mother's Day — gift bouquets unknowingly toxic"],"exposure_routes":"Oral ingestion (chewing plant), oral grooming (pollen from fur), oral (drinking vase water)"},"exposure":{"routes":["oral"],"contact_types":["oral_ingestion","oral_grooming"],"users":["pet_cat"],"duration":"acute","frequency":"rare","scenarios":["Cat chews leaves or petals from cut flowers in household bouquet","Cat brushes against pollen-laden stamens — grooms pollen from coat (oral exposure)","Cat drinks vase water containing lily stems","Easter-season Lilium longiflorum gift bouquet placed in cat-accessible room","Mother's Day mixed bouquet with tiger/Asiatic lilies — owner unaware of cat-specific toxicity"],"notes":"TOXIN UNIDENTIFIED — no specific compound hq_id available; this product file is intentionally compound-empty pending Phase 56 SCI-14 lily-toxin identification research. Multiple candidate fractions (steroidal glycoalkaloids, glycosaminoglycans, water-soluble unidentified factor) have been investigated without definitive identification. Mechanism: acute renal tubular necrosis with characteristic histopathology. Toxic species: Lilium longiflorum (Easter lily), Lilium tigrinum (tiger lily), Lilium speciosum, Lilium auratum, all Asiatic and oriental lily hybrids; Hemerocallis (daylily) genus. NOT toxic via this mechanism: Calla lily (Zantedeschia), peace lily (Spathiphyllum), peruvian lily (Alstroemeria), lily of the valley (Convallaria majalis — different toxicity, cardiac glycosides). Dose: 2-3 leaves or 1 stamen sufficient. Time-to-onset: vomiting within 2-6 hours, depression within 12 hours, oliguria/anuria within 18-72 hours, renal failure death 3-7 days untreated. Treatment: aggressive IV fluid diuresis within 18 hours of exposure (ideally <6 hours); decontamination (induced emesis if <2 hours, activated charcoal); hemodialysis for established anuric ARF. Mortality without treatment: ~100%; mortality with treatment within 18 hours: 25-50%; mortality with delayed (>18 hour) presentation: >90%."},"consumer_guidance":{"usage_warning":"DO NOT bring any true lily (Lilium genus) or daylily (Hemerocallis genus) into a household with cats. This includes Easter lilies, tiger lilies, Asiatic lilies, Oriental lilies, and all daylily varieties. Inspect gift bouquets — refuse or remove lilies before bringing flowers home. If exposure is suspected, contact a veterinarian or ASPCA APCC (1-888-426-4435) IMMEDIATELY — do not wait for symptoms. Time-to-treatment <18 hours is the most important survival predictor. Even pollen on fur is sufficient for fatal exposure — bathe the cat if pollen contact is suspected and proceed to emergency care. Calla lilies (Zantedeschia) and peace lilies (Spathiphyllum) are botanically NOT lilies — they cause oral irritation from calcium oxalate crystals but not the renal-failure syndrome.","safer_alternatives":["Cat-safe cut flowers — roses, gerbera daisies, sunflowers, snapdragons, alstroemeria","Silk/artificial bouquets where cut flowers are desired","Lily-free seasonal gifting protocol — request 'no lilies' on flower delivery orders","ASPCA Toxic and Non-Toxic Plant List as cross-reference before any cut flower or houseplant purchase","Verify Easter / Mother's Day gift bouquets at delivery — remove lilies immediately if present"]},"regulatory":{"applicable_regulations":[{"jurisdiction":"USA","regulation":"ASPCA APCC plant-toxicity surveillance + AVMA","citation":"Voluntary; ASPCA APCC database serves as de facto national registry","requirements":"No federal regulation of ornamental-plant pet-toxicity labeling. ASPCA APCC publishes Toxic and Non-Toxic Plant List as consumer education.","compliance_status":null,"effective_date":null,"enforcing_agency":"AVMA / ASPCA APCC","penalties":null,"source_ref":null}],"certifications":[],"labeling":{"required_disclosures":[],"prop65_warning":{"required":null,"chemicals":[],"endpoint":null,"notes":null},"ghs_labeling":{"required":null,"signal_word":null,"pictograms":[],"hazard_statements":[],"notes":null},"hidden_ingredients":{"trade_secret_protected":null,"categories_hidden":[],"estimated_count":null,"known_concerns":null,"notes":null},"notes":null},"recalls":[],"regulatory_gap":null,"notes":null},"lifecycle":{"recyclable":false,"disposal_guidance":"Discard contaminated lily plant material in sealed bag in outdoor trash inaccessible to pets. Pour vase water down drain (aquatic toxicity not documented but prudent disposal recommended).","hazardous_waste":false,"expected_lifespan":"cut flowers 5-14 days"},"formulation":{"form":"varies","key_ingredients":[],"certifications":[]},"materials":{"common":[],"concerning":[],"preferred":[]},"compound_composition":[],"identifiers":{"common_names":["lily ingestion and feline acute renal failure (lilium and hemerocallis species — easter, tiger, daylily, asiatic — unidentified toxin, 100% mortality without treatment)"],"aliases":[],"manufacturer":null,"brands":[]},"brand_examples":[],"brand_examples_disclaimer":null,"sources":[{"type":"expert_curation","name":"ALETHEIA Safety Database","date":"2026-05-08"}],"meta":{"schema_version":"4.0.0","last_updated":"2026-05-08","timestamp":"2026-06-11T20:57:33.427Z"},"_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer"}