{"hq_id":"hq-c-org-002119","name":"Pyrantel pamoate","context":"human_adult","risk_level":"low","schema":"legacy","note":"Synthesis unavailable: compound lacks vectorizable regulatory classifications. Raw safety data returned.","data":{"risk_level":"low","summary":"Pyrantel pamoate is the pamoate (embonate) salt form of pyrantel (free base catalogued as hq-c-org-000559 in this corpus). The salt's poor water solubility is THE pharmacologic feature — it's intentionally non-absorbed from the GI tract, giving high local intestinal concentration to paralyze nematode neuromuscular junctions (depolarizing nicotinic agonist) while keeping systemic exposure minimal. Clinical use: companion animal dewormer (cats, dogs, horses) at 5-10 mg/kg pyrantel base equivalent for ascarids (Toxocara canis, T. cati) and hookworms (Ancylostoma, Uncinaria); also human pinworm (Enterobius vermicularis) treatment OTC under Pin-X / Reese's Pinworm Medicine. AAFCO and FDA-CVM approved. Wide therapeutic margin; LD50 in rats >5000 mg/kg orally (very low acute toxicity due to non-absorbance). Adverse effects in pets are mild and transient: vomiting in ~5%, diarrhea, anorexia. Pregnant cats and queens with kittens under 4 weeks: standard veterinary caution. Resistance is documented in equine cyathostomes (small strongyles); monitoring via fecal egg count reduction is the modern best-practice. NOT effective against tapeworms (cestodes) — combination products pair pyrantel with praziquantel.","source_refs":["src_pubchem","src_phase62_batch"]},"meta":{"synthesis_version":"n/a","timestamp":"2026-07-27T03:49:12.583Z"},"_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult"]}