{"hq_id":"hq-c-org-002115","name":"Fludioxonil","context":"human_adult","risk_level":"low","schema":"legacy","note":"Synthesis unavailable: compound lacks vectorizable regulatory classifications. Raw safety data returned.","data":{"risk_level":"low","summary":"Fludioxonil is a phenylpyrrole fungicide derived from the natural antifungal pyrrolnitrin (produced by Pseudomonas fluorescens). It is one of the most widely used post-harvest fungicides globally, applied to citrus, stone fruit, pome fruit, potatoes, and cereals to prevent Botrytis, Penicillium, Rhizopus, and Aspergillus. Mechanism: inhibits MAP kinase signaling in fungi (osmotic stress pathway, specifically Group III histidine kinase), a target absent in mammals, contributing to its favorable safety profile. Relatively low mammalian toxicity: oral LD50 in rats >5000 mg/kg; ADI 0.37 mg/kg/day (EU). Classified as EPA toxicity category IV (practically non-toxic) for acute oral, dermal, and inhalation. At high doses in chronic studies, thyroid effects (follicular cell hypertrophy) and liver effects have been observed in rodents. EU approved; US EPA registered. Common post-harvest treatment: applied as a seed treatment (often in combination with metalaxyl/mefenoxam) or as a post-harvest dip/wax on fruit. MRLs well-established: EU 5-7 mg/kg on citrus, 5 mg/kg on stone fruit.","source_refs":["aletheia_fungi_batch_2026"]},"meta":{"synthesis_version":"n/a","timestamp":"2026-07-27T02:33:51.556Z"},"_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult"]}