{"hq_id":"hq-c-org-002099","name":"Mycophenolic Acid","context":"human_adult","risk_level":"moderate","schema":"legacy","note":"Synthesis unavailable: compound lacks vectorizable regulatory classifications. Raw safety data returned.","data":{"risk_level":"moderate","summary":"Mycophenolic acid (MPA) is a meroterpenoid mycotoxin produced by Penicillium roqueforti, P. brevicompactum, and P. carneum, commonly found in silage, blue cheese, and as a contaminant of grain and indoor environments. It is also a critically important pharmaceutical: mycophenolate mofetil (CellCept) and mycophenolate sodium (Myfortic) are prodrugs of MPA used as immunosuppressants in organ transplant rejection prophylaxis and autoimmune diseases. Mechanism: MPA is a potent, selective, reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH) type II, the rate-limiting enzyme in de novo purine synthesis in lymphocytes. This selectively suppresses T and B cell proliferation. As a mycotoxin in silage: MPA at concentrations of 25-50 mg/kg has been associated with reduced feed intake and immunosuppression in cattle. Blue cheese contains 0.15-1.5 mg/kg MPA — dietary exposure from cheese is considered low risk for immunocompetent adults. FDA pregnancy category D (teratogenic): mycophenolate causes ear, facial, cardiac, and digital malformations. REMS program required for pharmaceutical use.","source_refs":["aletheia_fungi_batch_2026"]},"meta":{"synthesis_version":"n/a","timestamp":"2026-05-13T22:14:35.355Z"}}