{"hq_id":"hq-c-org-002071","name":"Alachlor","context":"human_adult","timestamp":"2026-10-28T18:58:33.708Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"04299bbd676bc92d0c102bae2005f007c261b8ed","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"5feba6939b7e14ce7bc7b932c365e48d8a2cc4db6f0796f4e2a8f8f11126f719","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-002071","sha256":"2892ad188591116e6d0b141f24131e862e0a2aea813f1598193398ac2631d5b6"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.695983,"weightedMean":0.695983,"std_dev":0.045553,"confidence_interval_95":[0.625,0.75],"source_positions":[{"source":"EPA","year":1998,"value":0.75,"weight":0.41},{"source":"IARC","year":2025,"value":0.7,"weight":0.67158},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.741765,"weightedMean":0.741765,"std_dev":0.13753,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2025,"value":0.82,"weight":0.67158},{"source":"EPA","year":1998,"value":0.82,"weight":0.41}]},"recency":{"mean":0.771891,"weightedMean":0.771891,"std_dev":0.186907,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2025,"value":0.819,"weight":0.67158},{"source":"EPA","year":1998,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.926654,"weightedMean":0.926654,"std_dev":0.128934,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2025,"value":1,"weight":0.67158},{"source":"EPA","year":1998,"value":1,"weight":0.41}]},"specificity":{"mean":0.791562,"weightedMean":0.791562,"std_dev":0.073063,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2025,"value":0.75,"weight":0.67158},{"source":"EPA","year":1998,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.696313,"disagreement_magnitude":0.227897,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA classifies as higher risk (75th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"r60-2026-09-30-d907-4d64e08f23","type":"iarc","title":"IARC Monographs evaluation of the carcinogenicity of atrazine, alachlor, and vinclozolin – IARC","url":"https://www.iarc.who.int/news-events/iarc-monographs-evaluation-of-the-carcinogenicity-of-atrazine-alachlor-and-vinclozolin/"},{"id":"r60-2026-09-26-d867-cc2-epa-dwsha-2018-tables","type":"regulatory","title":"US EPA, Drinking Water Standards and Health Advisories Tables (2018 Edition)","url":"https://www.epa.gov/system/files/documents/2022-01/dwtable2018.pdf"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:EU:banned — not approved under regulation (ec) 1107/2"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":5,"warnings":["unmapped_classification:EU:banned — not approved under regulation (ec) 1107/2"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","agricultural_worker"]}