{"hq_id":"hq-c-org-002022","name":"Chlorine dioxide (ClO2)","context":"human_adult","timestamp":"2026-10-27T17:55:06.962Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-002022","sha256":"2894b7fa742106f5ffee87ce88443dcfe14e6e5704c6e2483d1c7c3555d53ce3"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.35,"weightedMean":0.35,"std_dev":0,"confidence_interval_95":[0.35,0.35],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"src_001","type":"regulatory","title":"OSHA: Chlorine Dioxide Safety and Health Topics","year":2015,"url":"https://www.osha.gov"},{"id":"src_002","type":"government","title":"EPA: Chlorine Dioxide in Drinking Water","year":2018,"url":"https://www.epa.gov/wtr-treatment/chlorine-dioxide"},{"id":"src_003","type":"journal","title":"Chlorine dioxide-related respiratory injury following water damage remediation","year":2022},{"id":"src_004","type":"government","title":"NIOSH Alert: Ozone, Chlorine Dioxide, and Other Biocides Used in Flooded Homes","year":1996,"url":"https://www.cdc.gov/niosh"},{"id":"r60-2026-09-29-d899-s1-b05-niosh-npg-nengapdxg-appendix-g","type":"regulatory","title":"Air Contaminants Update Project | NIOSH | CDC","url":"https://www.cdc.gov/niosh/npg/nengapdxg.html"},{"id":"r60-2026-09-25-d867-niosh-npg-npgd0116","type":"regulatory","title":"CDC - NIOSH Pocket Guide to Chemical Hazards - Chlorine dioxide","url":"https://www.cdc.gov/niosh/npg/npgd0116.html"},{"id":"r60-2026-09-25-d867-ecfr-29cfr1926-subpartD","type":"regulatory","title":"Subpart D—Occupational Health and Environmental Controls","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-01/title-29.xml?part=1926&subpart=D"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-09-26-d867-cc2-ecfr-40cfr141.64","type":"regulatory","title":"§ 141.64 Maximum contaminant levels for disinfection byproducts.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-24/title-40.xml?part=141&section=141.64"},{"id":"r60-2026-09-26-d867-cc2-ecfr-40cfr141.65","type":"regulatory","title":"§ 141.65 Maximum residual disinfectant levels.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-24/title-40.xml?part=141&section=141.65"},{"id":"r60-2026-09-28-d899-s2-b02-epa-npdwr-table","type":"regulatory","title":"National Primary Drinking Water Regulations | US EPA","url":"https://www.epa.gov/ground-water-and-drinking-water/national-primary-drinking-water-regulations"},{"id":"r60-2026-09-27-d820-osha-annotated-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1 | Occupational Safety and Health Administration","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-09-30-d899-s2-b11-iris-landing-496-chlorine-dioxide","type":"regulatory","title":"Chlorine dioxide | CASRN 10049-04-4 | DTXSID5023958 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=496"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"pubchem-computed-cid-24870","type":"database","title":"PubChem computed properties for CID 24870 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/24870"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"r60-2026-09-26-d867-cc1-eurlex-cellar-02008R1272-20260701","type":"regulatory","title":"Consolidated TEXT: 32008R1272 — EN — 01.07.2026 (Regulation (EC) No 1272/2008, CLP; the consolidation applicable on 2026-09-26)","url":"https://publications.europa.eu/resource/celex/02008R1272-20260701"},{"id":"d974-o14-2026-10-03-d968-ecfr-40cfr180-s180.1364","type":"regulatory","title":"40 CFR Part 180 (eCFR text as of 24 September 2026): § 180.1364 Chlorate; exemption from the requirement of a tolerance.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-25/title-40.xml?part=180"},{"id":"pubchem-computed-structure-cid-24870","type":"database","title":"PubChem computed structure descriptors for CID 24870 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/24870"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:EPA:registered for drinking water treatment under sdwa","unmapped_classification:OSHA:pel 0.1 ppm twa (niosh rel st 0.3 ppm)","unmapped_classification:FDA:fda has issued multiple warning letters against mm","unmapped_classification:EU BPR:approved active substance under bpr for product ty","unmapped_classification:EPA CTX / IRIS:carcinogenic potential cannot be determined","unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":12,"warnings":["unmapped_classification:EPA:registered for drinking water treatment under sdwa","unmapped_classification:OSHA:pel 0.1 ppm twa (niosh rel st 0.3 ppm)","unmapped_classification:FDA:fda has issued multiple warning letters against mm","unmapped_classification:EU BPR:approved active substance under bpr for product ty","unmapped_classification:EPA CTX / IRIS:carcinogenic potential cannot be determined","unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","dog","cat","environmental","human_teen","human_elderly","human_infant","human_pregnant","agricultural_worker"]}