{"hq_id":"hq-c-org-001498","name":"3-MCPD (3-Monochloropropane-1,2-diol)","context":"human_adult","timestamp":"2026-10-27T17:55:57.140Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-001498","sha256":"bd4c6bcae8a15ebfee6bcd793d00609015e120388f1db4018e1b069e8a50acd3"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.557566,"weightedMean":0.557566,"std_dev":0.062305,"confidence_interval_95":[0.5,0.625],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35},{"source":"IARC","year":2013,"value":0.5,"weight":0.41}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2013,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2013,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2013,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2013,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.584633,"disagreement_magnitude":0.312066,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. HQ_DIRECT classifies as higher risk (63th percentile), while IARC concludes lower risk (50th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"src_efsa_2018","type":"regulatory_body","url":"https://efsa.onlinelibrary.wiley.com/doi/full/10.2903/j.efsa.2018.5083"},{"id":"src_iarc_2012","type":"regulatory_body"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"ctx_pred_dtxsid4020664","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID4020664 (3-MCPD (3-Monochloropropane-1,2-diol))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID4020664"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:EFSA:tdi of 2 microg/kg bw/day established","unmapped_classification:EU Commission:maximum levels in vegetable oils established","unmapped_classification:JECFA:pmtdi of 4 microg/kg bw/day (2016, under review)","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":9,"warnings":["unmapped_classification:EFSA:tdi of 2 microg/kg bw/day established","unmapped_classification:EU Commission:maximum levels in vegetable oils established","unmapped_classification:JECFA:pmtdi of 4 microg/kg bw/day (2016, under review)"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","human_infant","human_pregnant","human_teen","human_elderly"]}