{"hq_id":"hq-c-org-001498","name":"3-MCPD (3-Monochloropropane-1,2-diol)","context":"human_adult","timestamp":"2026-05-01T19:37:00.593Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.557566,"weightedMean":0.557566,"std_dev":0.062305,"confidence_interval_95":[0.625,0.625],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35},{"source":"IARC","year":2012,"value":0.5,"weight":0.41}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2012,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2012,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2012,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2012,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.584633,"disagreement_magnitude":0.312066,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. HQ_DIRECT classifies as higher risk (63th percentile), while IARC concludes lower risk (50th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[],"warnings":["unmapped_classification:EFSA:tdi of 2 microg/kg bw/day established","unmapped_classification:EU Commission:maximum levels in vegetable oils established","unmapped_classification:JECFA:pmtdi of 4 microg/kg bw/day (2016, under review)","limited_synthesis"],"meta":{"synthesis_version":"1.0.0","config_version":"1.0.0","n_sources":2,"db_version":5,"warnings":["unmapped_classification:EFSA:tdi of 2 microg/kg bw/day established","unmapped_classification:EU Commission:maximum levels in vegetable oils established","unmapped_classification:JECFA:pmtdi of 4 microg/kg bw/day (2016, under review)"]},"schema":"synthesis"}