{"hq_id":"hq-c-org-001028","name":"Hydrochlorothiazide","context":"human_adult","timestamp":"2026-10-27T17:02:07.488Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-001028","sha256":"c706ca2d9c737393477119d5cc57289f7a8f0e119a2626ce60750c74488eb5d8"}]},"risk_level":"severe","risk_profile":{"magnitude":{"mean":0.725641,"weightedMean":0.725641,"std_dev":0.343413,"confidence_interval_95":[0.2,0.95],"source_positions":[{"source":"IARC","year":2026,"value":0.95,"weight":0.82},{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.724274,"weightedMean":0.724274,"std_dev":0.146523,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2026,"value":0.82,"weight":0.82}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2026,"value":1,"weight":0.82}]},"methodology":{"mean":0.910256,"weightedMean":0.910256,"std_dev":0.137365,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2026,"value":1,"weight":0.82}]},"specificity":{"mean":0.800855,"weightedMean":0.800855,"std_dev":0.07784,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2026,"value":0.75,"weight":0.82}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.395929,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (20th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"src_001","type":"database","title":"PubChem","year":2026},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"PROPOSITION 65 LIST OF CARCINOGENS OR REPRODUCTIVE TOXICANTS","year":2026,"url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"pubchem-computed-cid-3639","type":"database","title":"PubChem computed properties for CID 3639 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/3639"},{"id":"ctx_pred_dtxsid2020713","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID2020713 (Hydrochlorothiazide)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID2020713"},{"id":"pubchem-computed-structure-cid-3639","type":"database","title":"PubChem computed structure descriptors for CID 3639 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/3639"},{"id":"pubchem-exp-human-metabolome-database-cid-3639","type":"database","title":"Human Metabolome Database (HMDB), as recorded by PubChem (Experimental Properties, CID 3639; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/3639/JSON?heading=Experimental+Properties"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:US FDA:regulated as pharmaceutical (fda/ema); not typical","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":14,"warnings":["unmapped_classification:US FDA:regulated as pharmaceutical (fda/ema); not typical"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_teen","human_elderly","human_infant","human_pregnant"]}