{"hq_id":"hq-c-org-001006","name":"Cumene","context":"human_adult","timestamp":"2026-09-10T06:55:33.954Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.462821,"weightedMean":0.462821,"std_dev":0.182826,"confidence_interval_95":[0.2,0.65],"source_positions":[{"source":"NTP","year":2014,"value":0.65,"weight":0.41},{"source":"IARC","year":2013,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.724274,"weightedMean":0.724274,"std_dev":0.146523,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2013,"value":0.82,"weight":0.41},{"source":"NTP","year":2014,"value":0.82,"weight":0.41}]},"recency":{"mean":0.649573,"weightedMean":0.649573,"std_dev":0.228942,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2013,"value":0.5,"weight":0.41},{"source":"NTP","year":2014,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.910256,"weightedMean":0.910256,"std_dev":0.137365,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2013,"value":1,"weight":0.41},{"source":"NTP","year":2014,"value":1,"weight":0.41}]},"specificity":{"mean":0.800855,"weightedMean":0.800855,"std_dev":0.07784,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2013,"value":0.75,"weight":0.41},{"source":"NTP","year":2014,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.335052,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. NTP classifies as higher risk (65th percentile), while HQ_DIRECT concludes lower risk (20th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"src_001","type":"database","title":"PubChem","year":2026},{"id":"iarc_101_cumene","type":"regulatory","title":"IARC Monograph Volume 101 — Cumene (Group 2B — Possibly carcinogenic to humans)","year":2013},{"id":"ntp_roc_cumene","type":"regulatory","title":"NTP Report on Carcinogens, 15th ed. (2021) — Cumene (Reasonably anticipated to be a human carcinogen; first listed 13th RoC, 2014)","year":2021,"url":"https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cumene.pdf"},{"id":"epa_cumene_iris","type":"regulatory","title":"EPA IRIS — Cumene Toxicological Review (RfC framework, kidney + liver endpoints)","year":1997},{"id":"niosh_cumene_pocket_guide","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards — Cumene (CAS 98-82-8)","year":2019},{"id":"osha_cumene_pel","type":"regulatory","title":"OSHA PEL — Cumene (29 CFR 1910.1000 Table Z-1, with skin notation)","year":2020},{"id":"atsdr_cumene_tox_profile","type":"regulatory","title":"ATSDR Toxicological Profile — Cumene","year":2014},{"id":"echa_reach_cumene","type":"regulatory","title":"ECHA REACH Dossier — Cumene harmonised classification (H226 flammable, H332 inhalation, H304 aspiration, H411 aquatic)","year":2020}],"sources_scope":"record","meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":8},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_dermal","exposure_ocular","exposure_inhalation","occupational_exposure","human_teen","human_elderly","human_infant","human_pregnant","aquatic_life","exposure_ingestion"]}