{"hq_id":"hq-c-org-001006","name":"Cumene","context":"human_adult","timestamp":"2026-10-27T17:54:51.474Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-001006","sha256":"6a415cbacabb5c04901db7f17b8759f333e349bb70d8f61489612e43cf90ac43"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.462821,"weightedMean":0.462821,"std_dev":0.182826,"confidence_interval_95":[0.2,0.65],"source_positions":[{"source":"NTP","year":2014,"value":0.65,"weight":0.41},{"source":"IARC","year":2013,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.724274,"weightedMean":0.724274,"std_dev":0.146523,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2013,"value":0.82,"weight":0.41},{"source":"NTP","year":2014,"value":0.82,"weight":0.41}]},"recency":{"mean":0.649573,"weightedMean":0.649573,"std_dev":0.228942,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2013,"value":0.5,"weight":0.41},{"source":"NTP","year":2014,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.910256,"weightedMean":0.910256,"std_dev":0.137365,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2013,"value":1,"weight":0.41},{"source":"NTP","year":2014,"value":1,"weight":0.41}]},"specificity":{"mean":0.800855,"weightedMean":0.800855,"std_dev":0.07784,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2013,"value":0.75,"weight":0.41},{"source":"NTP","year":2014,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.335052,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. NTP classifies as higher risk (65th percentile), while HQ_DIRECT concludes lower risk (20th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"src_001","type":"database","title":"PubChem","year":2026},{"id":"iarc_101_cumene","type":"regulatory","title":"IARC Monograph Volume 101 — Cumene (Group 2B — Possibly carcinogenic to humans)","year":2013},{"id":"ntp_roc_cumene","type":"regulatory","title":"NTP Report on Carcinogens, 15th ed. (2021) — Cumene (Reasonably anticipated to be a human carcinogen; first listed 13th RoC, 2014)","year":2021,"url":"https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cumene.pdf"},{"id":"epa_cumene_iris","type":"regulatory","title":"EPA IRIS — Cumene Toxicological Review (RfC framework, kidney + liver endpoints)","year":1997},{"id":"niosh_cumene_pocket_guide","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards — Cumene (CAS 98-82-8)","year":2019,"url":"https://www.cdc.gov/niosh/npg/npgd0159.html"},{"id":"osha_cumene_pel","type":"regulatory","title":"OSHA PEL — Cumene (29 CFR 1910.1000 Table Z-1, with skin notation)","year":2020,"url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"atsdr_cumene_tox_profile","type":"regulatory","title":"ATSDR Toxicological Profile — Cumene","year":2014},{"id":"echa_reach_cumene","type":"regulatory","title":"ECHA REACH Dossier — Cumene harmonised classification (H226 flammable, H332 inhalation, H304 aspiration, H411 aquatic)","year":2020},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"src_pubchem_tox_7406","type":"pubchem","title":"PubChem: Toxicity section (CID 7406)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/7406/JSON?heading=Toxicity"},{"id":"r60-2026-09-27-d820-osha-annotated-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-09-25-d897-eu-cellar-02019L1831-20191031","type":"regulatory","title":"Consolidated TEXT: 32019L1831 — EN — 31.10.2019","url":"https://publications.europa.eu/resource/celex/02019L1831-20191031"},{"id":"pubchem-computed-cid-7406","type":"database","title":"PubChem computed properties for CID 7406 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/7406"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC's List of Classifications DATA, as the IARC list page loads it","url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-ntp-roc-15th-listed-substances","type":"regulatory","title":"NTP Report on Carcinogens, 15th Edition — Substances Listed (public domain)","url":"https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/listed_substances_508.pdf"},{"id":"src_pubchem_exp_7406","type":"pubchem","title":"PubChem: Experimental Properties section (CID 7406)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/7406/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid1021827","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID1021827 (Cumene)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID1021827"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"pubchem-computed-structure-cid-7406","type":"database","title":"PubChem computed structure descriptors for CID 7406 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/7406"}],"sources_scope":"record","derived_markers":[],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":12},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_dermal","exposure_ocular","exposure_inhalation","occupational_exposure","human_teen","human_elderly","human_infant","human_pregnant","aquatic_life","exposure_ingestion"]}