{"hq_id":"hq-c-org-000876","name":"Pyridine","context":"human_adult","timestamp":"2026-09-10T09:46:14.808Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.430921,"weightedMean":0.430921,"std_dev":0.074766,"confidence_interval_95":[0.35,0.5],"source_positions":[{"source":"IARC","year":2019,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2019,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2019,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2019,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2019,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.50156,"disagreement_magnitude":0.314261,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"src_001","type":"database","title":"PubChem","year":2026},{"id":"iarc_119_pyridine","type":"regulatory","title":"IARC Monographs Volume 119 (2019) — Pyridine (Group 2B — possibly carcinogenic to humans; supersedes Volume 77's Group 3)","year":2019},{"id":"epa_pyridine_iris","type":"regulatory","title":"EPA IRIS — Pyridine Toxicological Review (RfD framework, hepatic + neurological endpoints)","year":2002},{"id":"niosh_pyridine_pocket_guide","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards — Pyridine (CAS 110-86-1)","year":2019},{"id":"osha_pyridine_pel","type":"regulatory","title":"OSHA PEL — Pyridine (29 CFR 1910.1000 Table Z-1)","year":2020},{"id":"atsdr_pyridine_tox_profile","type":"regulatory","title":"ATSDR Toxicological Profile — Pyridine","year":1992},{"id":"ntp_pyridine_bioassay","type":"study","title":"NTP Technical Report — Pyridine carcinogenesis bioassay (rat liver-tumor cohort)","year":2000},{"id":"echa_reach_pyridine","type":"regulatory","title":"ECHA REACH Dossier — Pyridine harmonised classification (H225 flammable, H302 acute oral, H315/H319 irritation)","year":2020}],"sources_scope":"record","warnings":["limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":8},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_dermal","exposure_ocular","exposure_inhalation","occupational_exposure","human_teen","human_elderly","human_infant","human_pregnant","exposure_ingestion"]}