{"hq_id":"hq-c-org-000830","name":"2-Methoxyethanol (EGME)","context":"human_adult","timestamp":"2026-10-27T17:55:19.241Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000830","sha256":"dfba5daa1bdadb36fde27e4634099db8494a095891957d7056cfd31b9758b852"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.625,"weightedMean":0.625,"std_dev":0,"confidence_interval_95":[0.625,0.625],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates high risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"src_001","type":"database","title":"PubChem Compound Database","year":2026},{"id":"niosh_egme_pocket_guide","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards — 2-Methoxyethanol / EGME (CAS 109-86-4, skin notation, reproductive hazard)","year":2019,"url":"https://www.cdc.gov/niosh/npg/npgd0401.html"},{"id":"niosh_glycol_ether_alert_1991","type":"regulatory","title":"NIOSH Current Intelligence Bulletin 53 — Glycol Ether Reproductive Toxicity Alert (EGME, EGEE, and acetate analogues)","year":1991},{"id":"osha_egme_pel","type":"regulatory","title":"OSHA PEL — 2-Methoxyethanol (29 CFR 1910.1000 Table Z-1, with skin notation)","year":2020,"url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"echa_reach_egme_svhc","type":"regulatory","title":"ECHA REACH SVHC — 2-Methoxyethanol (Reproductive toxicity Cat 1B, Authorisation Annex XIV)","year":2010},{"id":"atsdr_glycol_ethers_tox_profile","type":"regulatory","title":"ATSDR Toxicological Profile — Ethylene glycol ethers (EGME, EGEE, and acetates)","year":2017},{"id":"epa_egme_iris","type":"regulatory","title":"EPA IRIS — 2-Methoxyethanol RfC framework (testicular + developmental endpoints)","year":1991,"url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=525"},{"id":"eu_clp_egme_classification","type":"regulatory","title":"EU CLP Regulation — 2-Methoxyethanol harmonised classification (H360FD reproductive toxicant Cat 1B + skin H312)","year":2020},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-09-27-d820-osha-annotated-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-09-25-d897-eu-cellar-02004L0037-20240408","type":"regulatory","title":"Consolidated TEXT: 32004L0037 — EN — 08.04.2024","url":"https://publications.europa.eu/resource/celex/02004L0037-20240408"},{"id":"pubchem-computed-cid-8019","type":"database","title":"PubChem computed properties for CID 8019 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/8019"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"src_pubchem_exp_8019","type":"pubchem","title":"PubChem: Experimental Properties section (CID 8019)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/8019/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid5024182","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID5024182 (2-Methoxyethanol (EGME))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID5024182"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"pubchem-computed-structure-cid-8019","type":"database","title":"PubChem computed structure descriptors for CID 8019 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/8019"},{"id":"r60-2026-10-18-a5oj-eu-cellar-32008r1272-oj","type":"regulatory","title":"Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006: Annex VI, Part 3, Table 3.1 (Official Journal L 353, 31.12.2008)","year":2008,"url":"https://publications.europa.eu/resource/celex/32008R1272"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:EDC Assessment:suspected endocrine disruptor","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":12,"warnings":["unmapped_classification:EDC Assessment:suspected endocrine disruptor"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_pregnant","exposure_dermal","exposure_ocular","human_child","exposure_inhalation","occupational_exposure","human_teen","human_elderly","human_infant","exposure_ingestion"]}