{"hq_id":"hq-c-org-000830","name":"2-Methoxyethanol (EGME)","context":"human_adult","timestamp":"2026-08-28T01:29:11.500Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.625,"weightedMean":0.625,"std_dev":0,"confidence_interval_95":[0.625,0.625],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate to high risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"src_001","type":"database","title":"PubChem Compound Database","year":2026},{"id":"niosh_egme_pocket_guide","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards — 2-Methoxyethanol / EGME (CAS 109-86-4, skin notation, reproductive hazard)","year":2019},{"id":"niosh_glycol_ether_alert_1991","type":"regulatory","title":"NIOSH Current Intelligence Bulletin 53 — Glycol Ether Reproductive Toxicity Alert (EGME, EGEE, and acetate analogues)","year":1991,"url":"https://www.cdc.gov/niosh/docs/83-112/"},{"id":"osha_egme_pel","type":"regulatory","title":"OSHA PEL — 2-Methoxyethanol (29 CFR 1910.1000 Table Z-1, with skin notation)","year":2020},{"id":"echa_reach_egme_svhc","type":"regulatory","title":"ECHA REACH SVHC — 2-Methoxyethanol (Reproductive toxicity Cat 1B, Authorisation Annex XIV)","year":2010},{"id":"atsdr_glycol_ethers_tox_profile","type":"regulatory","title":"ATSDR Toxicological Profile — Ethylene glycol ethers (EGME, EGEE, and acetates)","year":2017},{"id":"epa_egme_iris","type":"regulatory","title":"EPA IRIS — 2-Methoxyethanol RfC framework (testicular + developmental endpoints)","year":1991},{"id":"eu_clp_egme_classification","type":"regulatory","title":"EU CLP Regulation — 2-Methoxyethanol harmonised classification (H360FD reproductive toxicant Cat 1B + skin H312)","year":2020}],"sources_scope":"record","warnings":["unmapped_classification:EDC Assessment:suspected endocrine disruptor","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":8,"warnings":["unmapped_classification:EDC Assessment:suspected endocrine disruptor"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_pregnant","exposure_dermal","exposure_ocular","human_child","exposure_inhalation","occupational_exposure","human_teen","human_elderly","human_infant","exposure_ingestion"]}