{"hq_id":"hq-c-org-000779","name":"α-Thujone","context":"human_adult","timestamp":"2026-10-27T17:56:43.903Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000779","sha256":"69cd8adcc9174f9d4e666820fba02b8e1187956451320a5d603a0054091e138e"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.625,"weightedMean":0.625,"std_dev":0,"confidence_interval_95":[0.625,0.625],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates high risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"src_001","type":"database","title":"PubChem Compound Database","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/261491"},{"id":"fda_thujone_food_additive_21cfr","type":"regulatory","title":"FDA 21 CFR 172.510 — Thujone permitted in food only when present in plant materials (Artemisia + Salvia + Salvia officinalis at <10 ppm thujone-equivalents in finished food); banned as added pure substance","year":2018},{"id":"ifra_standard_thujone_2024","type":"regulatory","title":"IFRA Standard 51st Amendment — α + β-Thujone in fragrance products (GABA-A antagonist convulsant restriction; finished-product limits per product category)","year":2024},{"id":"efsa_thujone_2016","type":"regulatory","title":"EFSA Scientific Opinion on α + β-Thujone (FGE.31 — Maximum permitted levels in alcoholic beverages 35 mg/L spirits ≤25% alcohol + 10 mg/L bitters / 5 mg/L liqueurs and dietary food)","year":2016},{"id":"eu_thujone_alcoholic_beverages_2008","type":"regulatory","title":"EU Regulation (EC) No 1334/2008 on flavourings — α + β-Thujone maximum permitted concentrations in absinthe + bitter alcoholic beverages","year":2008},{"id":"hold_thujone_gaba_antagonist_2000","type":"study","title":"Höld KM, Sirisoma NS, Ikeda T, Narahashi T, Casida JE — α-Thujone (the active component of absinthe): γ-aminobutyric acid type A receptor modulation and metabolic detoxification (mechanism + LD50 + chronic-cohort framework, PNAS)","year":2000},{"id":"r60-2026-09-29-d899-s3-b05-cellar-02008R1334-20260216","type":"regulatory","title":"Consolidated TEXT: 32008R1334 — EN — 16.02.2026","url":"https://publications.europa.eu/resource/celex/02008R1334-20260216"},{"id":"pubchem-computed-cid-261491","type":"database","title":"PubChem computed properties for CID 261491 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/261491"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-human-metabolome-database-cid-261491","type":"database","title":"Human Metabolome Database (HMDB), as recorded by PubChem (Experimental Properties, CID 261491; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/261491/JSON?heading=Experimental+Properties"},{"id":"pubchem-computed-structure-cid-261491","type":"database","title":"PubChem computed structure descriptors for CID 261491 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/261491"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:EDC Assessment:suspected endocrine disruptor","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":11,"warnings":["unmapped_classification:EDC Assessment:suspected endocrine disruptor"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","human_pregnant","exposure_ingestion","human_teen","human_elderly","human_infant","exposure_dermal","exposure_inhalation","exposure_ocular","occupational_exposure"]}