{"hq_id":"hq-c-org-000777","name":"Massoia bark oil","context":"human_adult","timestamp":"2026-10-27T21:13:40.631Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000777","sha256":"bddec8fed7f89edce6197f2a045c2627534995d1c99cedff263752b1c9a2a0f9"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.625,"weightedMean":0.625,"std_dev":0,"confidence_interval_95":[0.625,0.625],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates high risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"src_001","type":"database","title":"PubChem Compound Database","year":2026,"url":null},{"id":"ifra_standard_massoia_2024","type":"regulatory","title":"IFRA Standard 51st Amendment — Massoia bark oil (Cryptocarya massoia) prohibited from leave-on skin-contact fragrance products (potent skin sensitizer + acute-irritation framework)","year":2024},{"id":"eu_cosmetics_massoia_annex_ii","type":"regulatory","title":"EU Cosmetics Regulation 1223/2009 Annex II + Annex III — C10 + C12 massoia lactone restriction in finished cosmetic products","year":2009},{"id":"rifm_massoia_lactone_review","type":"study","title":"RIFM (Research Institute for Fragrance Materials) — Massoia lactone fragrance-ingredient toxicology profile + Local Lymph Node Assay sensitization framework","year":2018},{"id":"council_europe_massoia_natural_sources","type":"regulatory","title":"Council of Europe — Active Principles in Natural Sources of Flavourings — Massoia bark oil + C10 lactone sensitizer-restriction framework","year":2014},{"id":"fda_otc_massoia_fragrance_use","type":"regulatory","title":"FDA Voluntary Cosmetic Registration Program (VCRP) + Food/Cosmetic Industry Self-Regulation — Massoia bark oil restricted to wash-off + low-concentration applications per IFRA framework alignment","year":2018},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"}],"sources_scope":"record","derived_markers":[],"warnings":["single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":9},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ocular","occupational_exposure"]}