{"hq_id":"hq-c-org-000775","name":"Allyl isothiocyanate","context":"human_adult","timestamp":"2026-10-27T20:55:29.689Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000775","sha256":"52fdc2f7cc6daa3eb2fcb75780a10463a76da77ccc106e1d7aa4ed81ee52bd8f"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.475,"weightedMean":0.475,"std_dev":0,"confidence_interval_95":[0.475,0.475],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.475,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate to high risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"src_001","type":"database","title":"PubChem Compound Database","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/5971"},{"id":"fda_gras_allyl_isothiocyanate","type":"regulatory","title":"FDA 21 CFR 184.1409 + 21 CFR 582.10 — Allyl isothiocyanate generally recognized as safe (GRAS) for use as flavoring agent (mustard-essential-oil principal component; volatile + lacrimator)","year":2018},{"id":"iarc_73_allyl_isothiocyanate","type":"regulatory","title":"IARC Monographs Volume 73 — Allyl Isothiocyanate (Group 3 Not classifiable as to its carcinogenicity to humans; sensitization + lacrimator framework)","year":1999},{"id":"ifra_standard_aitc_2024","type":"regulatory","title":"IFRA Standard 51st Amendment — Allyl isothiocyanate concentration limits in finished fragrance products (sensitization + acute-irritation framework; finished-product 0.001-0.1% by category)","year":2024},{"id":"niosh_allyl_isothiocyanate_pocket_guide","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards — Allyl Isothiocyanate (CAS 57-06-7; PEL 0.4 mg/m³ + 4 mg/m³ STEL; lacrimator) [citation withdrawn 2026-09-29]","year":2019},{"id":"efsa_glucosinolates_2008","type":"regulatory","title":"EFSA Scientific Opinion on Glucosinolates as Undesirable Substances in Animal Feed — sinigrin + allyl isothiocyanate hydrolysis-product framework + Brassica feed-quality limits","year":2008},{"id":"pubchem-computed-cid-5971","type":"database","title":"PubChem computed properties for CID 5971 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/5971"},{"id":"src_pubchem_exp_5971","type":"pubchem","title":"PubChem: Experimental Properties section (CID 5971)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/5971/JSON?heading=Experimental+Properties"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"ctx_pred_dtxsid3020047","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID3020047 (Allyl isothiocyanate)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID3020047"},{"id":"pubchem-computed-structure-cid-5971","type":"database","title":"PubChem computed structure descriptors for CID 5971 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/5971"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:US FDA:regulated under food safety frameworks (fda gras, ","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":15,"warnings":["unmapped_classification:US FDA:regulated under food safety frameworks (fda gras, "]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ocular","occupational_exposure"]}