{"hq_id":"hq-c-org-000769","name":"Pulegone","context":"human_adult","timestamp":"2026-10-27T20:53:46.743Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000769","sha256":"0c394c9ce391eba419d29333ee4cd84d32636b000a0712251a6f0977b22e1506"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.557566,"weightedMean":0.557566,"std_dev":0.062305,"confidence_interval_95":[0.5,0.625],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35},{"source":"IARC","year":2016,"value":0.5,"weight":0.41}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2016,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2016,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2016,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2016,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.584633,"disagreement_magnitude":0.312066,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. HQ_DIRECT classifies as higher risk (63th percentile), while IARC concludes lower risk (50th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"src_001","type":"database","title":"PubChem Compound Database","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/442495"},{"id":"fda_aers_pennyroyal_hepatotoxicity","type":"regulatory","title":"FDA Adverse Event Reporting System — Pennyroyal Oil + Pulegone Hepatotoxicity Case-Fatality Framework (Anderson et al. 1996 case-series; abortifacient-misuse fatality cluster)","year":1996},{"id":"ifra_standard_pulegone_2024","type":"regulatory","title":"IFRA Standard 51st Amendment — Pulegone in fragrance products (skin-allergen + reproductive-toxicity + hepatotoxicity restriction; usage-level limits per product category)","year":2024},{"id":"efsa_pulegone_menthofuran_2016","type":"regulatory","title":"EFSA Scientific Opinion on Pulegone and Menthofuran in Flavourings (FGE.92 + FGE.92.Rev.1 — restriction of pulegone-bearing herbal products in foodstuffs; herbal-tea cohort analysis)","year":2016},{"id":"eu_cosmetics_pulegone_annex_iii","type":"regulatory","title":"EU Cosmetics Regulation 1223/2009 Annex III — Pulegone restriction (toothpaste + leave-on/rinse-off product limits per concentration framework)","year":2009},{"id":"anderson_pennyroyal_jama_1996","type":"study","title":"Anderson IB, Mullen WH, Meeker JE et al. — Pennyroyal toxicity: measurement of toxic metabolite levels in two cases and review of the literature (canonical pennyroyal-oil/pulegone-fatality cohort, JAMA Internal Medicine)","year":1996},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"pubchem-computed-cid-442495","type":"database","title":"PubChem computed properties for CID 442495 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/442495"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-442495","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 442495; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/442495/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid2025975","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID2025975 (Pulegone)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID2025975"},{"id":"pubchem-computed-structure-cid-442495","type":"database","title":"PubChem computed structure descriptors for CID 442495 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/442495"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:EDC Assessment:suspected endocrine disruptor","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":13,"warnings":["unmapped_classification:EDC Assessment:suspected endocrine disruptor"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_pregnant","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","exposure_dermal","exposure_inhalation","exposure_ocular","occupational_exposure"]}