{"hq_id":"hq-c-org-000769","name":"Pulegone","context":"human_adult","timestamp":"2026-08-28T02:45:43.884Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.625,"weightedMean":0.625,"std_dev":0,"confidence_interval_95":[0.625,0.625],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate to high risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"src_001","type":"database","title":"PubChem Compound Database","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/442495"},{"id":"fda_aers_pennyroyal_hepatotoxicity","type":"regulatory","title":"FDA Adverse Event Reporting System — Pennyroyal Oil + Pulegone Hepatotoxicity Case-Fatality Framework (Anderson et al. 1996 case-series; abortifacient-misuse fatality cluster)","year":1996},{"id":"ifra_standard_pulegone_2024","type":"regulatory","title":"IFRA Standard 51st Amendment — Pulegone in fragrance products (skin-allergen + reproductive-toxicity + hepatotoxicity restriction; usage-level limits per product category)","year":2024},{"id":"efsa_pulegone_menthofuran_2016","type":"regulatory","title":"EFSA Scientific Opinion on Pulegone and Menthofuran in Flavourings (FGE.92 + FGE.92.Rev.1 — restriction of pulegone-bearing herbal products in foodstuffs; herbal-tea cohort analysis)","year":2016},{"id":"eu_cosmetics_pulegone_annex_iii","type":"regulatory","title":"EU Cosmetics Regulation 1223/2009 Annex III — Pulegone restriction (toothpaste + leave-on/rinse-off product limits per concentration framework)","year":2009},{"id":"anderson_pennyroyal_jama_1996","type":"study","title":"Anderson IB, Mullen WH, Meeker JE et al. — Pennyroyal toxicity: measurement of toxic metabolite levels in two cases and review of the literature (canonical pennyroyal-oil/pulegone-fatality cohort, JAMA Internal Medicine)","year":1996}],"sources_scope":"record","warnings":["unmapped_classification:EDC Assessment:suspected endocrine disruptor","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":7,"warnings":["unmapped_classification:EDC Assessment:suspected endocrine disruptor"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_pregnant","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","exposure_dermal","exposure_inhalation","exposure_ocular","occupational_exposure"]}