{"hq_id":"hq-c-org-000761","name":"Calamus oil (beta-asarone)","context":"human_adult","timestamp":"2026-10-27T20:52:55.283Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000761","sha256":"cb992088fcd0ab44cf3f914e540c472f49137c42cd5bef51995bb1c5a4cfaf2b"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.625,"weightedMean":0.625,"std_dev":0,"confidence_interval_95":[0.625,0.625],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates high risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"src_001","type":"database","title":"PubChem Compound Database","year":2026,"url":null},{"id":"fda_21cfr_189_110_calamus","type":"regulatory","title":"FDA 21 CFR 189.110 — Calamus and its derivatives prohibited as food substances (banned 1968 based on β-asarone hepatocarcinogenicity in B6C3F1 mouse cohort; substance + extract + oil + tincture all banned)","year":1968},{"id":"iarc_56_betaasarone","type":"regulatory","title":"IARC Monographs Volume 10 + Supplement 7 + Volume 56 — Calamus (β-asarone Group 2B Possibly Carcinogenic to Humans; rodent hepatocarcinogenicity)","year":1987},{"id":"efsa_asarone_2002","type":"regulatory","title":"EFSA Scientific Committee on Food — α + β-Asarone (Acorus calamus) opinion (genotoxic carcinogen — ALARA principle; flavouring-restriction framework)","year":2002},{"id":"ifra_standard_calamus_2024","type":"regulatory","title":"IFRA Standard 51st Amendment — Acorus calamus oil + derivatives prohibited from fragrance use (β-asarone genotoxicity + IARC 2B classification basis)","year":2024},{"id":"council_europe_betaasarone","type":"regulatory","title":"Council of Europe — Active Principles (Constituents of Toxicological Concern) Contained in Natural Sources of Flavourings — β-Asarone genotoxic-carcinogen restriction","year":2014},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:EDC Assessment:suspected endocrine disruptor","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":9,"warnings":["unmapped_classification:EDC Assessment:suspected endocrine disruptor"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_pregnant","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","exposure_dermal","exposure_inhalation","exposure_ocular","occupational_exposure"]}