{"hq_id":"hq-c-org-000701","name":"Methyl methacrylate (MMA)","context":"human_adult","timestamp":"2026-05-29T17:46:43.000Z","risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.356001,"weightedMean":0.356001,"std_dev":0.208678,"confidence_interval_95":[0.25,0.625],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.25,"weight":0.30176},{"source":"EPA CTX / IRIS","year":2021,"value":0.15,"weight":0.30176}]},"confidence":{"mean":0.70254,"weightedMean":0.70254,"std_dev":0.154241,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.599983,"weightedMean":0.599983,"std_dev":0.304626,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.889882,"weightedMean":0.889882,"std_dev":0.144601,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.8124,"weightedMean":0.8124,"std_dev":0.081941,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.411424,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. HQ_DIRECT classifies as higher risk (63th percentile), while EPA CTX / IRIS concludes lower risk (15th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[],"warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / IARC:2021","unmapped_classification:EPA CTX / IRIS:e (evidence of non-carcinogenicity for humans)","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":39,"warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / IARC:2021","unmapped_classification:EPA CTX / IRIS:e (evidence of non-carcinogenicity for humans)","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive"]},"schema":"synthesis"}