{"hq_id":"hq-c-org-000671","name":"2,4-Toluene diisocyanate","context":"human_adult","timestamp":"2026-09-10T20:19:16.953Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.583836,"weightedMean":0.583836,"std_dev":0.067207,"confidence_interval_95":[0.5,0.65],"source_positions":[{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35},{"source":"IARC","year":1999,"value":0.5,"weight":0.41}]},"confidence":{"mean":0.714515,"weightedMean":0.714515,"std_dev":0.150427,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"IARC","year":1999,"value":0.82,"weight":0.41}]},"recency":{"mean":0.627305,"weightedMean":0.627305,"std_dev":0.26675,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"IARC","year":1999,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.901108,"weightedMean":0.901108,"std_dev":0.141025,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"IARC","year":1999,"value":1,"weight":0.41}]},"specificity":{"mean":0.806039,"weightedMean":0.806039,"std_dev":0.079914,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"IARC","year":1999,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.551953,"disagreement_magnitude":0.352519,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / NTP RoC classifies as higher risk (65th percentile), while IARC concludes lower risk (50th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"src_001","type":"database","title":"PubChem Compound CID 11443","url":"https://pubchem.ncbi.nlm.nih.gov/compound/11443"},{"id":"src_002","type":"epa","title":"EPA CompTox Chemicals Dashboard — DTXSID7026156","url":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026156"},{"id":"src_003","type":"reference","title":"ATSDR Toxicological Profile — CAS 584-84-9","url":"https://www.atsdr.cdc.gov/toxprofiledocs/index.html"}],"sources_scope":"context","warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":47,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["aquatic_life","cat","dog","exposure_dermal","exposure_inhalation","exposure_ocular","human_adult","human_child","human_teen","human_elderly","human_infant","human_pregnant","exposure_ingestion","occupational_exposure"]}