{"hq_id":"hq-c-org-000671","name":"2,4-Toluene diisocyanate","context":"human_adult","timestamp":"2026-10-27T17:57:27.996Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000671","sha256":"aea96e13d55e14d885fe4a3d3d5aa61b0195209228f4a4e0536629a1ee659b09"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.583836,"weightedMean":0.583836,"std_dev":0.067207,"confidence_interval_95":[0.5,0.65],"source_positions":[{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35},{"source":"IARC","year":1999,"value":0.5,"weight":0.41}]},"confidence":{"mean":0.714515,"weightedMean":0.714515,"std_dev":0.150427,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"IARC","year":1999,"value":0.82,"weight":0.41}]},"recency":{"mean":0.627305,"weightedMean":0.627305,"std_dev":0.26675,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"IARC","year":1999,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.901108,"weightedMean":0.901108,"std_dev":0.141025,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"IARC","year":1999,"value":1,"weight":0.41}]},"specificity":{"mean":0.806039,"weightedMean":0.806039,"std_dev":0.079914,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"IARC","year":1999,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.551953,"disagreement_magnitude":0.352519,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / NTP RoC classifies as higher risk (65th percentile), while IARC concludes lower risk (50th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"src_001","type":"database","title":"PubChem Compound CID 11443","url":"https://pubchem.ncbi.nlm.nih.gov/compound/11443"},{"id":"src_002","type":"epa","title":"EPA CompTox Chemicals Dashboard — DTXSID7026156","url":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026156"},{"id":"src_003","type":"reference","title":"ATSDR Toxicological Profile — CAS 584-84-9","url":"https://www.atsdr.cdc.gov/toxprofiledocs/index.html"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-cameo-chemicals-cid-11443","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 11443; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/11443/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid7026156","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID7026156 (2,4-Toluene diisocyanate)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID7026156"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":50,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["aquatic_life","cat","dog","exposure_dermal","exposure_inhalation","exposure_ocular","human_adult","human_child","human_teen","human_elderly","human_infant","human_pregnant","exposure_ingestion","occupational_exposure"]}