{"hq_id":"hq-c-org-000666","name":"Diuron (3-(3,4-dichlorophenyl)-1,1-dimethylurea)","context":"human_adult","timestamp":"2026-10-27T20:20:06.956Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000666","sha256":"7dc117e5cf846485762a98a7b34552397bcfb59ed9b18209d3a837ebca692e38"}]},"risk_level":"severe","risk_profile":{"magnitude":{"mean":0.719941,"weightedMean":0.719941,"std_dev":0.074986,"confidence_interval_95":[0.625,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.75,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.70254,"weightedMean":0.70254,"std_dev":0.154241,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.599983,"weightedMean":0.599983,"std_dev":0.304626,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.889882,"weightedMean":0.889882,"std_dev":0.144601,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.8124,"weightedMean":0.8124,"std_dev":0.081941,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.500093,"disagreement_magnitude":0.356749,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"src_001","type":"database","title":"PubChem Compound CID 3120","url":"https://pubchem.ncbi.nlm.nih.gov/compound/3120"},{"id":"src_002","type":"epa","title":"EPA CompTox Chemicals Dashboard — DTXSID0020446","url":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020446"},{"id":"src_003","type":"reference","title":"ATSDR Toxicological Profile — CAS 330-54-1","url":"https://www.atsdr.cdc.gov/toxprofiledocs/index.html"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"PROPOSITION 65 LIST OF CARCINOGENS OR REPRODUCTIVE TOXICANTS","year":2026,"url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-28-d449-fr-E7-11205-72FR32533-raw","type":"regulatory","title":"72 FR 32533 (2007-06-13) FR Doc E7-11205: Diuron; Pesticide Tolerance","url":"https://www.federalregister.gov/documents/full_text/text/2007/06/13/E7-11205.txt"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_3120","type":"pubchem","title":"PubChem: Toxicity section (CID 3120)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/3120/JSON?heading=Toxicity"},{"id":"r60-2026-10-03-d923-niosh-npgd0247","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards - Diuron","url":"https://www.cdc.gov/niosh/npg/npgd0247.html"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-3120","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 3120; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/3120/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid0020446","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID0020446 (Diuron (3-(3,4-dichlorophenyl)-1,1-dimethylurea))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID0020446"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:EPA CTX / EPA OPP:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":47,"warnings":["year_inferred:EPA CTX / EPA OPP:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["aquatic_life","exposure_ingestion","human_adult","human_child","human_teen","human_elderly","human_infant","human_pregnant","agricultural_worker"]}