{"hq_id":"hq-c-org-000630","name":"Tremolite Asbestos","context":"human_adult","timestamp":"2026-10-27T21:03:14.653Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000630","sha256":"37b4a19d91686133e32bb7a7b3966a6e0f41d6bdf5ce2b88761bbf35783363cc"}]},"risk_level":"extreme","risk_profile":{"magnitude":{"mean":0.95,"weightedMean":0.95,"std_dev":0,"confidence_interval_95":[0.95,0.95],"source_positions":[{"source":"IARC","year":2012,"value":0.95,"weight":0.41}]},"confidence":{"mean":0.82,"weightedMean":0.82,"std_dev":0,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"IARC","year":2012,"value":0.82,"weight":0.41}]},"recency":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"IARC","year":2012,"value":0.5,"weight":0.41}]},"methodology":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"IARC","year":2012,"value":1,"weight":0.41}]},"specificity":{"mean":0.75,"weightedMean":0.75,"std_dev":0,"confidence_interval_95":[0.75,0.75],"source_positions":[{"source":"IARC","year":2012,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (IARC, 2012) indicates extreme risk.","confidence_note":"High-quality evidence exists across sources. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"src_001","type":"regulatory","title":"IARC Monographs Supplement 7 (1987) — Asbestos (Group 1)","year":1987,"url":"https://inchem.org/documents/iarc/suppl7/asbestos.html"},{"id":"src_002","type":"regulatory","title":"FDA Testing of J&J Talc Lots for Asbestos Contamination (2019 Report)","year":2019},{"id":"src_004","type":"journal","title":"Mesothelioma risk among those exposed to chrysotile asbestos only and mixtures that include amphibole: a case–control study in the USA, 1975–1980","year":2020,"url":"https://pubmed.ncbi.nlm.nih.gov/33087407/"},{"id":"src_jnj_reuters_2018","type":"investigative_journalism","title":"Johnson & Johnson knew for decades that asbestos lurked in its Baby Powder","year":2018,"url":"https://www.reuters.com/investigates/special-report/johnsonandjohnson-cancer/"},{"id":"src_jnj_settlement_2023","type":"court_record","title":"LTL Management bankruptcy reorganization — proposed J&J talc settlement","year":2023},{"id":"iarc_100c_asbestos","type":"regulatory","title":"IARC Monographs Volume 100C: Arsenic, Metals, Fibres, and Dusts","year":2012,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304374/"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1001","type":"regulatory","title":"§ 1910.1001 Asbestos.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1001"},{"id":"r60-2026-09-24-d869-iarc-monographs-available","type":"regulatory","title":"IARC Monographs — Monographs available (index)","year":2026,"url":"https://monographs.iarc.who.int/monographs-available/"},{"id":"r60-2026-09-26-d867-cc3-niosh-npg-npgd0041","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards - Asbestos (1332-21-4) (reached from the NPG CAS index npgdcas.html, archived 2026-09-25)","url":"https://www.cdc.gov/niosh/npg/npgd0041.html"},{"id":"pubchem-computed-cid-131634194","type":"database","title":"PubChem computed properties for CID 131634194 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/131634194"},{"id":"r60-iarc-100c-asbestos-group1","type":"regulatory","title":"IARC Monographs Vol 100C (2012) — Asbestos (Arsenic, Metals, Fibres and Dusts)","url":"https://www.ncbi.nlm.nih.gov/books/NBK304374/"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-131634194","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 131634194; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/131634194/JSON?heading=Experimental+Properties"},{"id":"pubchem-computed-structure-cid-131634194","type":"database","title":"PubChem computed structure descriptors for CID 131634194 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/131634194"}],"sources_scope":"record","derived_markers":[],"warnings":["single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":33},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","human_teen","human_elderly","human_infant","human_pregnant"]}