{"hq_id":"hq-c-org-000624","name":"Perfluoroheptanoic acid (PFHpA)","context":"human_adult","timestamp":"2026-10-27T20:54:59.274Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000624","sha256":"df4a3b021c649e5c6e0baf9550ce9dc4829945a0cacacf58cc63f096f89c7013"}]},"risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"pfhpa_375-85-9_c7_pfca_intermediate_chain_eu_20pfas_ucmr5","type":"regulatory","title":"PFHpA Perfluoroheptanoic acid CAS 375-85-9 C7HF13O2 Not IARC Classified; C7 Intermediate Short-Chain (C4-C6) vs Long-Chain (C8+) PFAS Category; ECHA REACH Long-Chain PFCA C7-C18 Definition vs EPA Short vs Long-Chain; Serum Half-Life ~1-2 Years Intermediate PFHxA vs PFOA; PPARα Hepatotoxicity Developmental Thyroid Rodent Potency Intermediate; 6:2 FTOH 7:1 FTOH 8:2 FTOH Atmospheric OH Radical Degradation Precursor; Arctic Snow Ice Remote Atmospheric Deposition; EU DWD 2020/2184 Sum 20 PFAS 0.1 µg/L; EPA UCMR5 EPA Method 537.1 Monitoring; No April 2024 US MCL; WHO 2022 Drinking Water Guidelines PFHpA Included; EU REACH Universal PFAS Restriction 2023 Proposal All PFAS; EU EFSA Sum 20 PFAS Exposure Assessment Development; REACH 2017/1000 C9-C14 PFCA Restriction PFHpA Not Explicitly Covered; Marine Fish Seafood ng/g Levels AFFF Contamination Proximity","year":2024},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"pubchem-computed-cid-67818","type":"database","title":"PubChem computed properties for CID 67818 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/67818"},{"id":"doc-2026-10-02-d975-www-atsdr-cdc-gov-toxprofiles-tp200-pdf","type":"assessment","title":"Toxicological Profile for Perfluoroalkyls (ATSDR, Released May 2021)","url":"https://www.atsdr.cdc.gov/ToxProfiles/tp200.pdf"},{"id":"ctx_pred_dtxsid1037303","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID1037303 (Perfluoroheptanoic acid (PFHpA))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID1037303"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"pubchem-computed-structure-cid-67818","type":"database","title":"PubChem computed structure descriptors for CID 67818 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/67818"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:IARC:iarc — insufficient data for classification — perf","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":42,"warnings":["unmapped_classification:IARC:iarc — insufficient data for classification — perf"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}