{"hq_id":"hq-c-org-000622","name":"Phenanthrene","context":"human_adult","timestamp":"2026-08-28T02:57:22.103Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.226974,"weightedMean":0.226974,"std_dev":0.024922,"confidence_interval_95":[0.25,0.25],"source_positions":[{"source":"IARC","year":2010,"value":0.25,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2010,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2010,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2010,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2010,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.833853,"disagreement_magnitude":0.307831,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (25th percentile), while HQ_DIRECT concludes lower risk (20th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"phenanthrene_85-01-8_iarc_3_most_abundant_pah_angular_3ring","type":"regulatory","title":"Phenanthrene CAS 85-01-8 C14H10 1,2-Benznaphthalene IARC Group 3 Monograph 92 2010; Most Abundant PAH Environmental Matrices Urban Air 10-100 ng/m3 Road Dust 5-200 µg/g; Angular 3-Ring Bay Region C-4,5 vs Anthracene Linear No Bay Region; Phenanthrene Tetrol PheT Phenanthrene Dihydrodiol PAH Biomarker GC-MS/MS LC-MS/MS; Denissenko 1996 Science BPDE TP53 Hotspot Phenanthrene Model; 1-OHP + PheT Complementary Biomonitoring PAH Exposure; Ph/An Ratio Source Apportionment >10 Petrogenic <10 Pyrogenic; Phenanthrene Ring System Morphine Codeine Opiate Alkaloid Pharmacophore Core; Dual Pyrolytic Petrogenic Origin Poor Source Discriminator; Log Kow 4.5 Water Solubility 1200 µg/L Higher Biodegradation Rate; US EPA 16 Priority PAH; Not EU WFD Priority Substance; Coal Tar 1-5% Component; Petroleum Dominant PAH Dissolved Phase; Fittig Ostermayer 1872 Coal Tar Isolation","year":2010}],"sources_scope":"record","warnings":["unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 3 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 3 positive","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":46,"warnings":["unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 3 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 3 positive"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}