{"hq_id":"hq-c-org-000621","name":"Anthracene","context":"human_adult","timestamp":"2026-10-27T21:22:06.892Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000621","sha256":"1455795706e95e88c2f61e7a4dbe4df931dcc666e34c681347f846d2721df36a"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.383256,"weightedMean":0.383256,"std_dev":0.146267,"confidence_interval_95":[0.2,0.5],"source_positions":[{"source":"IARC","year":2024,"value":0.5,"weight":0.5494},{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.695473,"weightedMean":0.695473,"std_dev":0.156018,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2024,"value":0.82,"weight":0.5494}]},"recency":{"mean":0.798419,"weightedMean":0.798419,"std_dev":0.160894,"confidence_interval_95":[0.67,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2024,"value":0.67,"weight":0.5494}]},"methodology":{"mean":0.883256,"weightedMean":0.883256,"std_dev":0.146267,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2024,"value":1,"weight":0.5494}]},"specificity":{"mean":0.816155,"weightedMean":0.816155,"std_dev":0.082885,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2024,"value":0.75,"weight":0.5494}]},"consensus":{"exists":false,"strength":0.024887,"disagreement_magnitude":0.289896,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (20th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"anthracene_120-12-7_iarc_3_linear_3ring_phototoxic_wfd_svhc","type":"regulatory","title":"Anthracene (CAS 120-12-7, C14H10) — physicochemical, metabolic and ecotoxicological reference data","year":2010},{"id":"src_iarc_vol133","type":"iarc","title":"IARC Monographs Volume 133 — Anthracene, 2-bromopropane, butyl methacrylate, and dimethyl hydrogen phosphite (2024)","url":"https://www.iarc.who.int/news-events/iarc-monographs-evaluation-of-the-carcinogenicity-of-anthracene-2-bromopropane-butyl-methacrylate-and-dimethyl-hydrogen-phosphite/"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"pubchem_toxicity","type":"database","title":"PubChem PUG View, Toxicity section, CID 8418 (Anthracene)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/8418/JSON?heading=Toxicity"},{"id":"r60-2026-09-30-d899-s2-b10-iris-landing-434-anthracene","type":"regulatory","title":"Anthracene | CASRN 120-12-7 | DTXSID0023878 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=434"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"pubchem-computed-cid-8418","type":"database","title":"PubChem computed properties for CID 8418 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/8418"},{"id":"doc-2026-09-30-d907-4775674f6b","type":"assessment","title":"Toxicological Profile for Polycyclic Aromatic Hydrocarbons (ATSDR, August 1995)","url":"https://www.atsdr.cdc.gov/toxprofiles/tp69.pdf"},{"id":"doc-2026-10-03-d975-cfpub-epa-gov-ncea-pprtv-documents-anthracene-pdf","type":"assessment","title":"Provisional Peer-Reviewed Toxicity Values for Anthracene (CASRN 120-12-7), EPA/690/R-09/002F, Final, 6-15-2009","url":"https://cfpub.epa.gov/ncea/pprtv/documents/Anthracene.pdf"},{"id":"doc-2026-10-03-d975-iris-epa-gov-static-pdfs-0434-summary-pdf","type":"assessment","title":"Anthracene; CASRN 120-12-7: IRIS Chemical Assessment Summary","url":"https://iris.epa.gov/static/pdfs/0434_summary.pdf"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"doc-2026-10-03-d975-ecotox-ascii-09-15-2026","type":"database","title":"EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026","url":"https://gaftp.epa.gov/ecotox/ecotox_ascii_09_15_2026.zip"},{"id":"pubchem-exp-cameo-chemicals-cid-8418","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 8418; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/8418/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-pac-chemical-database-u-s-department-of--cid-8418","type":"database","title":"PAC Chemical Database, U.S. Department of Energy, as recorded by PubChem (Experimental Properties, CID 8418; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/8418/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-8418","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 8418; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/8418/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid0023878","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID0023878 (Anthracene)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID0023878"},{"id":"pubchem-computed-structure-cid-8418","type":"database","title":"PubChem computed structure descriptors for CID 8418 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/8418"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":50,"warnings":["unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"],"unsourced_values":["safety.dose_response.ld50"]}