{"hq_id":"hq-c-org-000620","name":"Fumonisin B2 (FB2)","context":"human_adult","timestamp":"2026-10-27T17:54:53.819Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000620","sha256":"b1e3020a564f857646f768b4c13e08b42a5a883cc9b967e86e98fa173f274681"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.407895,"weightedMean":0.407895,"std_dev":0.099688,"confidence_interval_95":[0.3,0.5],"source_positions":[{"source":"IARC","year":2002,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2002,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2002,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2002,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2002,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.335413,"disagreement_magnitude":0.319781,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"fb2_116355-84-1_iarc_2b_fumonisin_10-dehydroxy_maize","type":"regulatory","title":"Fumonisin B2 FB2 CAS 116355-84-1 C34H59NO14 IARC Group 2B Monograph 82 2002; 10-Dehydroxy-FB1 Structural Analog Sphinganine Ceramide Synthase CERS Inhibition Same Mechanism FB1; FB1:FB2:FB3 Ratio 60-70:20-25:5-10% Co-Occurrence Maize Fusarium verticillioides proliferatum; EFSA 2005 TDI 1 µg/kg bw/day Sum FB1+FB2+FB3; EU 1881/2006 Unprocessed Maize 4000 µg/kg Sum Fumonisins; Sa/So Ratio Biomarker Total Fumonisin Exposure; Nixtamalization Alkaline Hydrolysis Tricarballylic Ester 50-90% HFB2 Reduction; LC-MS/MS ELISA OPA Fluorescence Derivatization HPLC Detection; ELEM PPE Veterinary Disease Combined FB1+FB2 Natural Exposure; Maillard N-Carboxymethyl-FB2 Heat Masking","year":2002},{"id":"r60-2026-09-28-d899-s3-b02-pmc-PMC7009576-efsa-2018-5172-fumonisins-group-hbgv","type":"regulatory","title":"Appropriateness to set a group health‐based guidance value for fumonisins and their modified forms - PMC","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7009576/"},{"id":"r60-2026-09-26-d867-cc2-eu-cellar-02023R0915-20260819","type":"regulatory","title":"Consolidated TEXT: 32023R0915 — EN — 19.08.2026","url":"https://publications.europa.eu/resource/celex/02023R0915-20260819"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"pubchem-computed-cid-2733489","type":"database","title":"PubChem computed properties for CID 2733489 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/2733489"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"ctx_pred_dtxsid80891857","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID80891857 (Fumonisin B2 (FB2))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID80891857"},{"id":"pubchem-computed-structure-cid-2733489","type":"database","title":"PubChem computed structure descriptors for CID 2733489 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/2733489"}],"sources_scope":"record","derived_markers":[],"warnings":["limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":40},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}