{"hq_id":"hq-c-org-000619","name":"Ascorbyl palmitate (E304i)","context":"human_adult","timestamp":"2026-10-27T20:54:59.738Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000619","sha256":"798907eb4e651fb06cde8cb6f84994418ef1dfce843b109c2385079479b03bc2"}]},"risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"ascorbyl_palmitate_e304i_137-66-6_efsa2015_tocopherol","type":"regulatory","title":"Ascorbyl Palmitate CAS 137-66-6 L-Ascorbic Acid 6-Palmitate C22H38O7 E304i Amphiphilic Fat-Soluble Vitamin C; FDA GRAS 21 CFR 182.3149; EFSA 2015 EFSA Journal 13(5):4087 ADI 1.25 mg/kg/day E300-E304 Group; Hydrolysis Pancreatic Lipase GI Ascorbic Acid + Palmitic Acid; Lipid-Water Interface Positioning Lipophilic Tail Hydrophilic Ascorbate Head; Tocopherol Sparing Alpha-Tocopherol Peroxyl Radical Interception Tocopheroxyl Regeneration; Fish Oil Omega-3 Infant Formula DHA ARA Protection; Vitamin E Synergist; Enzymatic Esterification Immobilized Lipase Production; Pro-Oxidant In Vitro Fenton Fe2+ Metal-Catalyzed Condition; Net Antioxidant Food Use; Ascorbyl Stearate E304ii CAS 10605-09-1 C18 Analog","year":2015},{"id":"r60-2026-09-29-d899-s3-b05-pmc-PMC13189431-efsa-2015-4289-ascorbyl-palmitate","type":"regulatory","title":"Scientific Opinion on the re‐evaluation of ascorbyl palmitate (E 304(i)) and ascorbyl stearate (E 304(ii)) as food additives - PMC","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13189431/"},{"id":"r60-2026-09-29-d899-s3-b05-pmc-PMC7448004-efsa-2020-6153-ascorbyl-palmitate-follow-up","type":"regulatory","title":"Opinion on the re‐evaluation of ascorbyl palmitate (E 304i) as a food additive in foods for infants below 16 weeks of age and the follow‐up of its re‐evaluation as a food additive for uses in foods for all population groups - PMC","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7448004/"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_54680660","type":"pubchem","title":"PubChem: Toxicity section (CID 54680660)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/54680660/JSON?heading=Toxicity"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"pubchem-computed-cid-54680660","type":"database","title":"PubChem computed properties for CID 54680660 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/54680660"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"pubchem-exp-eu-food-improvement-agents-cid-54680660","type":"database","title":"EU Food Improvement Agents, as recorded by PubChem (Experimental Properties, CID 54680660; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/54680660/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid3041611","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID3041611 (Ascorbyl palmitate (E304i))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID3041611"},{"id":"pubchem-computed-structure-cid-54680660","type":"database","title":"PubChem computed structure descriptors for CID 54680660 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/54680660"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — ascorb","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":45,"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — ascorb","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}