{"hq_id":"hq-c-org-000619","name":"Ascorbyl palmitate (E304i)","context":"human_adult","timestamp":"2026-08-28T04:01:49.016Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"ascorbyl_palmitate_e304i_137-66-6_efsa2015_tocopherol","type":"regulatory","title":"Ascorbyl Palmitate CAS 137-66-6 L-Ascorbic Acid 6-Palmitate C22H38O7 E304i Amphiphilic Fat-Soluble Vitamin C; FDA GRAS 21 CFR 182.3149; EFSA 2015 EFSA Journal 13(5):4087 ADI 1.25 mg/kg/day E300-E304 Group; Hydrolysis Pancreatic Lipase GI Ascorbic Acid + Palmitic Acid Normal Dietary Components; Lipid-Water Interface Positioning Lipophilic Tail Hydrophilic Ascorbate Head; Tocopherol Sparing Alpha-Tocopherol Peroxyl Radical Interception Tocopheroxyl Regeneration; Fish Oil Omega-3 Infant Formula DHA ARA Protection; Vitamin E Synergist; Enzymatic Esterification Immobilized Lipase Production; Cosmetics Vitamin C Derivative Skin Care; Pro-Oxidant In Vitro Fenton Fe2+ Metal-Catalyzed Condition; Net Antioxidant Food Use; Ascorbyl Stearate E304ii CAS 10605-09-1 C18 Analog","year":2015}],"sources_scope":"record","warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — ascorb","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 2 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 2 positive","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":42,"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — ascorb","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 2 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 2 positive"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}