{"hq_id":"hq-c-org-000618","name":"Ascorbic acid (vitamin C; E300)","context":"human_adult","timestamp":"2026-08-28T02:42:42.440Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"ascorbic_acid_e300_50-81-7_vitamin_c_efsa2015_flour","type":"regulatory","title":"Ascorbic Acid L-Ascorbic Acid Vitamin C CAS 50-81-7 C6H8O6 pKa1 4.17 E300 FDA GRAS 21 CFR 182.3013 184.1033; EFSA ADI Not Specified; Essential Nutrient GULO Deficiency Humans No Endogenous Synthesis; Prolyl Lysyl Hydroxylase Collagen Scurvy; Dopamine Beta-Hydroxylase Norepinephrine; Carnitine PHM Peptide Amidation; Vitamin E Tocopheroxyl Radical Regeneration; Flour Improver: Ascorbic Acid Oxidase Dehydroascorbic Acid GS-H Oxidation Disulfide Strong Gluten Paradox; No Toxic By-Products Preferred EU vs Bromate ADA; Nitrite Cured Meat N-Nitrosamine Reduction E301 Sodium Ascorbate; Reichstein Synthesis 1933 Two-Step Fermentation China 80% 120000 Tonnes; RDA 75-90 mg/day UL 2000 mg/day; Oxalate High Dose >1000 mg Kidney Stone Risk; Pauling Megadose No RCT Cancer Benefit; IV High-Dose Pro-Oxidant Oncology Research","year":2015}],"sources_scope":"record","warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — ascorb","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 50 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 50 positiv","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":45,"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — ascorb","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 50 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 50 positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}