{"hq_id":"hq-c-org-000616","name":"Disodium EDTA (ethylenediaminetetraacetic acid)","context":"human_adult","timestamp":"2026-10-27T19:56:20.341Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000616","sha256":"366f436c1946d6739a339a7e320db9316547192f6548bb93590138690c1b4690"}]},"risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"disodium_edta_e385_139-33-3_efsa2004_chelation","type":"regulatory","title":"Disodium EDTA CAS 139-33-3 Na2-EDTA C10H14N2Na2O8 E385 Chelating Agent; FDA 21 CFR 172.120 Mayonnaise ≤75 ppm 172.135 Canned Legumes 172.145 Shellfish; JECFA ADI 2.5 mg/kg/day; EFSA 2004 EFSA Journal 2:39 ADI 2.5 mg/kg/day; Log K: Ca2+ 10.7 Mg2+ 8.7 Fe3+ 25.7 Zn2+ 16.1 Metal Stability Constants; CaNa2EDTA Calcium Form E385 Pre-Loaded Calcium Reduces GI Chelation; Mineral Chelation Ca Mg Zn Fe Absorption Reduction Marginal Status Concern; IV CaEDTA Lead Poisoning Treatment Standard of Care Blood Lead >45 µg/dL; Chelation Therapy Alternative Medicine Not FDA Approved; Environmental Persistence Resistant Biological WWTP European Rivers Groundwater µg/L; Metal Mobilization Sediment Fe Cd Pb Hg; EDDS GLDA IDS Biodegradable Alternatives; Lipid Oxidation Pro-Oxidant Metal Sequestration Fe Cu; Mayonnaise Salad Dressing Canned Food Shelf Life","year":2004},{"id":"efsa_2018_5369_ferric_sodium_edta_pmc","type":"regulatory","title":"Scientific opinion on the evaluation of authorised ferric sodium EDTA as an ingredient in the context of Regulation (EC) 258/97 on novel foods and Regulation (EU) 609/2013 on food intended for infants and young children, food for special medical purposes and total diet replacement for weight control","year":2018,"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7009604/"},{"id":"src_pubchem_tox_8759","type":"pubchem","title":"PubChem: Toxicity section (CID 8759)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/8759/JSON?heading=Toxicity"},{"id":"r60-2026-09-28-d899-s3-b03-cellar-02012R0231-20260818","type":"regulatory","title":"Cellar CELEX 02012R0231-20260818: Consolidated TEXT: 32012R0231 — EN — 18.08.2026 (Regulation (EU) No 231/2012, additive specifications)","url":"https://publications.europa.eu/resource/celex/02012R0231-20260818"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-8759","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 8759; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/8759/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid9027073","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID9027073 (Disodium EDTA (ethylenediaminetetraacetic acid))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID9027073"},{"id":"pubchem-computed-structure-cid-8759","type":"database","title":"PubChem computed structure descriptors for CID 8759 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/8759"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":48,"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}