{"hq_id":"hq-c-org-000612","name":"Isomalt (E953)","context":"human_adult","timestamp":"2026-10-27T20:15:58.581Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000612","sha256":"6f4169fd4dc2bd3a9691f07d3deea154d9a8145f639a9e7ea8c4507053d1165d"}]},"risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"isomalt_e953_64519-82-0_palatinit_hygroscopicity","type":"regulatory","title":"Isomalt CAS 64519-82-0 GPS 6-O-alpha-D-Glucopyranosyl-D-Sorbitol + GPM 1-O-alpha-D-Glucopyranosyl-D-Mannitol Equimolar Mixture E953 45-65% Sucrose 2.0 kcal/g; FDA GRAS GRN 000198; JECFA ADI Not Specified; EFSA ADI Not Specified; Bayer Palatinit 1960s Germany; Sucrose Isomerase Protaminobacter rubrum Isomaltulose Palatinose Then Raney Nickel Hydrogenation; GI ~2 Lowest Glycemic Polyols; Extremely Low Hygroscopicity vs Sucrose Hard Candy Sugar Sculpture Non-Sticky Humid; Heat Stable 175°C No Browning No Caramelization Glass-Clear; Halls Ricola Cough Drops; Sugar Pulling Blowing Competition Patisserie; Pharmaceutical Tablet Coating; Sucrase-Isomaltase Partial Hydrolysis Limited Glucose Release; Laxative 30-40g/day FDA Warning; Non-Cariogenic Glucosyltransferase Inhibition; Isomaltulose CAS 13718-94-0 GI 32 Sports Nutrition Functional Food Separate Ingredient","year":2005},{"id":"pubchem-computed-cid-3034828","type":"database","title":"PubChem computed properties for CID 3034828 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/3034828"},{"id":"src_pubchem_tox_3034828","type":"pubchem","title":"PubChem: Toxicity section (CID 3034828)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/3034828/JSON?heading=Toxicity"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"ctx_pred_dtxsid8020753","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID8020753 (Isomalt (E953))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID8020753"},{"id":"pubchem-computed-structure-cid-3034828","type":"database","title":"PubChem computed structure descriptors for CID 3034828 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/3034828"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — isomal","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":42,"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — isomal"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}