{"hq_id":"hq-c-org-000608","name":"Advantame (E969)","context":"human_adult","timestamp":"2026-10-27T19:06:11.434Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000608","sha256":"1d64308960f43218b606738f868073c8f6cee957e757edb843b1d04fb6831e3e"}]},"risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"advantame_e969_714229-20-6_fda2014_efsa2013","type":"regulatory","title":"Advantame CAS 714229-20-6 N-[N-[3-(3-Hydroxy-4-Methoxyphenyl)Propyl]-L-alpha-Aspartyl]-L-Phenylalanine 1-Methyl Ester C24H30N2O7 ~20000x Sucrose Most Potent Approved Sweetener; FDA Approved 2014 21 CFR 172.803; EU E969 2013; JECFA ADI 5 mg/kg/day 2011; EFSA ADI 5 mg/kg/day EFSA Journal 2013;11(7):3301 37 Studies All Negative; Isovanillin 3-Hydroxy-4-Methoxyphenylpropyl Group Vanilla Note Flavor Synergy; No PKU Warning Carboxypeptidase A Block No Free Phenylalanine; De-Esterified Advantame Major Metabolite; Ajinomoto Japan; Heat-Stable pH-Stable All Food Categories FDA; 1.5-2x More Potent Than Neotame; Limited Commercial Market Penetration Precision Dosing Required","year":2013},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"pubchem-computed-cid-56843846","type":"database","title":"PubChem computed properties for CID 56843846 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/56843846"},{"id":"ctx_pred_dtxsid00991787","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID00991787 (Advantame (E969))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID00991787"},{"id":"pubchem-computed-structure-cid-56843846","type":"database","title":"PubChem computed structure descriptors for CID 56843846 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/56843846"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — advant","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":42,"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — advant"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}