{"hq_id":"hq-c-org-000607","name":"Neotame (E961)","context":"human_adult","timestamp":"2026-10-27T18:50:31.199Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000607","sha256":"80b595802d70304bfad41fbda051e55e4fd8c6d100cfe1dde74404e0f03d0a02"}]},"risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"neotame_e961_165450-17-9_fda2002_efsa2007","type":"regulatory","title":"Neotame CAS 165450-17-9 N-[N-(3,3-Dimethylbutyl)-L-alpha-Aspartyl]-L-Phenylalanine 1-Methyl Ester C20H30N2O5 7000-13000x Sucrose; FDA Approved 2002 21 CFR 172.829 All Foods; EU E961 2010; JECFA ADI 2 mg/kg/day 2003; EFSA ADI 2 mg/kg/day EFSA Journal 2007;5(11):581; No PKU Warning Required 3,3-Dimethylbutyl Steric Block Carboxypeptidase A No Free Phenylalanine; T1R2/T1R3 Heterodimer Hydrophobic Neohexyl Binding Site Extra Affinity; De-Esterified Neotame Major Metabolite Methanol Negligible at ppb Use; NutraSweet 1992 Patent 2002 FDA Approval; 80+ Study Regulatory Package No Carcinogenicity Genotoxicity Neurotoxicity; Limited Commercial Adoption vs Aspartame Sucralose Stevia","year":2007},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"pubchem-computed-cid-9810996","type":"database","title":"PubChem computed properties for CID 9810996 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/9810996"},{"id":"src_pubchem_exp_9810996","type":"pubchem","title":"PubChem: Experimental Properties section (CID 9810996)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/9810996/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid50167950","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID50167950 (Neotame (E961))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID50167950"},{"id":"pubchem-computed-structure-cid-9810996","type":"database","title":"PubChem computed structure descriptors for CID 9810996 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/9810996"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — neotam","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":45,"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — neotam"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}