{"hq_id":"hq-c-org-000607","name":"Neotame (E961)","context":"human_adult","timestamp":"2026-08-28T01:30:20.441Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"neotame_e961_165450-17-9_fda2002_efsa2007","type":"regulatory","title":"Neotame CAS 165450-17-9 N-[N-(3,3-Dimethylbutyl)-L-alpha-Aspartyl]-L-Phenylalanine 1-Methyl Ester C20H30N2O5 7000-13000x Sucrose; FDA Approved 2002 21 CFR 172.829 All Foods; EU E961 2010; JECFA ADI 2 mg/kg/day 2003; EFSA ADI 2 mg/kg/day EFSA Journal 2007;5(11):581; No PKU Warning Required 3,3-Dimethylbutyl Steric Block Carboxypeptidase A No Free Phenylalanine; T1R2/T1R3 Heterodimer Hydrophobic Neohexyl Binding Site Extra Affinity; De-Esterified Neotame Major Metabolite Methanol Negligible at ppb Use; NutraSweet 1992 Patent 2002 FDA Approval; 80+ Study Regulatory Package No Carcinogenicity Genotoxicity Neurotoxicity; Limited Commercial Adoption vs Aspartame Sucralose Stevia","year":2007}],"sources_scope":"record","warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — neotam","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":41,"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — neotam"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}