{"hq_id":"hq-c-org-000604","name":"Vanillin (vanilla flavor; synthetic vanilla)","context":"human_adult","timestamp":"2026-10-27T18:03:15.687Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000604","sha256":"f02436cab95ad32315f48ace2e83e0619d0cfa8f40da031b6651a61d860a9dfc"}]},"risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"vanillin_121-33-5_jecfa_efsa2012_synthetic","type":"regulatory","title":"Vanillin CAS 121-33-5 4-Hydroxy-3-Methoxybenzaldehyde C8H8O3 FL04.010 FEMA 3107 No E-Number [NOTE: registry E466 entry incorrect — E466 is CMC/carboxymethylcellulose]; FDA GRAS 21 CFR 182.60 Synthetic Flavoring; JECFA ADI 10 mg/kg/day 1967 Confirmed; EFSA 2012 EFSA Journal 10(7):2817 No Safety Concern EDI 0.4-1.2 mg/person/day; Vanilla planifolia Bourbon Madagascar 1.5-3% Dry Bean; Synthetic 99%+ Market Guaiacol Glyoxylic Acid Process ~85% Production Lignin Borregaard Norway Eugenol Clove; Natural Label Biosynthetic Ferulic Acid Rice Bran Aspergillus Niger E. Coli; Labeling: Vanilla Extract 21 CFR 169 vs Artificial Flavor vs Natural Vanilla Flavor Biosynthetic; Vanillic Acid Homovanillic Acid Phenolic Metabolites Normal Diet; Anti-Sickling HbS Polymerization Research Zaugg 1977 Bookchin Not Food Safety; ~20000 Tonnes/Year Commercial Production; Madagascar Crop Cycle Price Volatility $100-600/kg Natural vs $15-25/kg Synthetic","year":2012},{"id":"r60-2026-09-30-d899-s4-b09-ecfr-21cfr169.175","type":"regulatory","title":"§ 169.175 Vanilla extract.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-25/title-21.xml?part=169&section=169.175"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_1183","type":"pubchem","title":"PubChem: Toxicity section (CID 1183)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/1183/JSON?heading=Toxicity"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"pubchem-computed-cid-1183","type":"database","title":"PubChem computed properties for CID 1183 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/1183"},{"id":"r60-2026-09-26-d867-cc1-eurlex-cellar-02009R1223-20260518","type":"regulatory","title":"Consolidated TEXT: 32009R1223 — EN — 18.05.2026 (Regulation (EC) No 1223/2009, cosmetic products)","url":"https://publications.europa.eu/resource/celex/02009R1223-20260518"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"pubchem-exp-cameo-chemicals-cid-1183","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 1183; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/1183/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-1183","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 1183; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/1183/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid0021969","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID0021969 (Vanillin (vanilla flavor; synthetic vanilla))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID0021969"},{"id":"pubchem-computed-structure-cid-1183","type":"database","title":"PubChem computed structure descriptors for CID 1183 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/1183"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — vanill","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":49,"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — vanill","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}