{"hq_id":"hq-c-org-000604","name":"Vanillin (vanilla flavor; synthetic vanilla)","context":"human_adult","timestamp":"2026-08-28T02:41:08.133Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"vanillin_121-33-5_jecfa_efsa2012_synthetic","type":"regulatory","title":"Vanillin CAS 121-33-5 4-Hydroxy-3-Methoxybenzaldehyde C8H8O3 FL04.010 FEMA 3107 No E-Number [NOTE: registry E466 entry incorrect — E466 is CMC/carboxymethylcellulose]; FDA GRAS 21 CFR 182.60 Synthetic Flavoring; JECFA ADI 10 mg/kg/day 1967 Confirmed; EFSA 2012 EFSA Journal 10(7):2817 No Safety Concern EDI 0.4-1.2 mg/person/day; Vanilla planifolia Bourbon Madagascar 1.5-3% Dry Bean; Synthetic 99%+ Market Guaiacol Glyoxylic Acid Process ~85% Production Lignin Borregaard Norway Eugenol Clove; Natural Label Biosynthetic Ferulic Acid Rice Bran Aspergillus Niger E. Coli; Labeling: Vanilla Extract 21 CFR 169 vs Artificial Flavor vs Natural Vanilla Flavor Biosynthetic; Vanillic Acid Homovanillic Acid Phenolic Metabolites Normal Diet; Anti-Sickling HbS Polymerization Research Zaugg 1977 Bookchin Not Food Safety; ~20000 Tonnes/Year Commercial Production; Madagascar Crop Cycle Price Volatility $100-600/kg Natural vs $15-25/kg Synthetic","year":2012}],"sources_scope":"record","warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — vanill","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 39 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 39 positiv","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":46,"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — vanill","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 39 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 39 positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}