{"hq_id":"hq-c-org-000601","name":"Disodium guanylate (GMP; E627)","context":"human_adult","timestamp":"2026-08-28T02:44:24.478Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"gmp_e627_efsa_shiitake_umami","type":"regulatory","title":"Disodium Guanylate GMP E627 CAS 5550-12-9 5'-GMP C10H12N5Na2O8P 2.3x More Potent Umami Synergist Than IMP; FDA GRAS EU E627 EFSA ADI Not Specified; I+G E631+E627 1:1 Commercial Blend Bouillon Noodles Snacks; Shiitake 5'-Nucleotidase Drying Activates RNA Hydrolysis GMP AMP IMP Natural Potent Umami Source; Dashi Kombu Glutamate + Katsuobushi Shiitake IMP GMP Synergy Origin; IMP Dehydrogenase XMP GMP Synthase Glutamine; cGMP Nitric Oxide Vasodilation Phosphodiesterase Retinal Phototransduction; Guanine Deaminase Xanthine Oxidase Uric Acid Gout Hyperuricemia Same As IMP; Yeast Saccharomyces Aspergillus Oryzae RNA Enzymatic Hydrolysis 5'-Phosphodiesterase; Halal Kosher Yeast-Derived Acceptable; Animal-Derived IMP Requires Certification; Vegetarian Label E631 E627 Source Ambiguity","year":2017}],"sources_scope":"record","warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — disodi","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 3 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 3 positive","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":38,"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — disodi","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 3 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 3 positive"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}