{"hq_id":"hq-c-org-000596","name":"Cellulose, microcrystalline (MCC; E460)","context":"human_adult","timestamp":"2026-10-27T17:00:51.358Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000596","sha256":"fb78417218a1dcda3f9f0a74020c2787f5cb7fdaafa1734a017b6b8b2e56ebf1"}]},"risk_level":"negligible","risk_profile":{"magnitude":{"mean":0.05,"weightedMean":0.05,"std_dev":0,"confidence_interval_95":[0.05,0.05],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.05,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates negligible risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"mcc_e460_efsa_2016","type":"regulatory","title":"Microcrystalline Cellulose MCC E460 CAS 9004-34-6 Avicel PH-101 PH-102 Wood Pulp Cotton Linters Acid Hydrolysis Crystalline Domains DP 220-350; EFSA 2016 ADI Not Specified EFSA Journal 2016;14(11):4659 Chronic 5% Diet 2500mg/kg; FDA GRAS 21 CFR 182.90 182.1480; Pharmaceutical Tablet Binder Direct Compression Plastic Deformation Cohesion; Disintegrant Capsule Filler Controlled-Release Matrix; Food Anticaking Texturizer Fat Replacer Emulsion Stabilizer; Avicel RC-591 MCC-CMC Coprocessed; Insoluble Dietary Fiber Minimal Fermentation Colon Stool Bulk; Not Carboxymethylcellulose Not HPMC Structurally Different; Universal Worldwide Regulatory Approval","year":2016},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-10-03-d923-niosh-npgd0110","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards - Cellulose","url":"https://www.cdc.gov/niosh/npg/npgd0110.html"},{"id":"r60-2026-09-27-d820-osha-annotated-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"doc-2026-10-03-d975-ecotox-ascii-09-15-2026","type":"database","title":"EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026","url":"https://gaftp.epa.gov/ecotox/ecotox_ascii_09_15_2026.zip"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — microc","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":29,"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — microc"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}