{"hq_id":"hq-c-org-000596","name":"Cellulose, microcrystalline (MCC; E460)","context":"human_adult","timestamp":"2026-08-28T01:28:13.790Z","risk_level":"negligible","risk_profile":{"magnitude":{"mean":0.05,"weightedMean":0.05,"std_dev":0,"confidence_interval_95":[0.05,0.05],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.05,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"mcc_e460_efsa_2016","type":"regulatory","title":"Microcrystalline Cellulose MCC E460 CAS 9004-34-6 Avicel PH-101 PH-102 Wood Pulp Cotton Linters Acid Hydrolysis Crystalline Domains DP 220-350; EFSA 2016 ADI Not Specified EFSA Journal 2016;14(11):4659 Chronic 5% Diet 2500mg/kg; FDA GRAS 21 CFR 182.90 182.1480; Pharmaceutical Tablet Binder Direct Compression Plastic Deformation Cohesion; Disintegrant Capsule Filler Controlled-Release Matrix; Food Anticaking Texturizer Fat Replacer Emulsion Stabilizer; Avicel RC-591 MCC-CMC Coprocessed; Insoluble Dietary Fiber Minimal Fermentation Colon Stool Bulk; Not Carboxymethylcellulose Not HPMC Structurally Different; Universal Worldwide Regulatory Approval","year":2016}],"sources_scope":"record","warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — microc","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":24,"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — microc"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}