{"hq_id":"hq-c-org-000591","name":"Beta-carotene (E160a; provitamin A)","context":"human_adult","timestamp":"2026-08-29T03:23:01.782Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"betacarotene_e160a_atbc_caret_iarc100e_2012","type":"regulatory","title":"Beta-Carotene E160a CAS 7235-40-7 CI Food Orange 5 All-Trans C40H56 Provitamin A Carotenoid; ATBC 1994 Finland N=29133 Male Smokers 20mg/day RR 1.18 16% Lung Cancer Increase; CARET 1996 USA N=18314 Smokers Asbestos Workers 30mg Beta-Carotene + 25000IU Retinol RR 1.28 28% Lung Cancer Trial Stopped Early; IARC Monograph Vol 100E 2012 Supplementation High-Dose Smokers; Mechanism Pro-Oxidant Beta-Apocarotenoxy CYP1A2 Retinoid Signaling RAR RXR P450; FDA GRAS 21 CFR 73.95 Exempt Color; EFSA ADI Not Specified Group; Dunaliella Salina Algal Production Blakeslea Trispora Fungal; BCMO1 Regulated Conversion No Vitamin A Toxicity From Beta-Carotene; Carotenodermia Orange Skin Benign Reversible; Protective Dietary Non-Supplement Non-Smoker Inverse Association Lung Cancer; Margarine Primary Food Application EU; WHO Pregnancy Vitamin A Deficiency Preferred Form","year":2012}],"sources_scope":"record","warnings":["unmapped_classification:IARC:not classified as a food colorant carcinogen; howe","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 47 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 47 positiv","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":41,"warnings":["unmapped_classification:IARC:not classified as a food colorant carcinogen; howe","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 47 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 47 positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","human_pregnant","aquatic_life","human_teen","human_elderly","human_infant"]}