{"hq_id":"hq-c-org-000590","name":"Curcumin (E100)","context":"human_adult","timestamp":"2026-10-27T21:04:05.965Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000590","sha256":"543b31700a9b551da3fd26c4ece92fb53c2eed1f696b6e9e722c25dc8aa4e8f2"}]},"risk_level":"negligible","risk_profile":{"magnitude":{"mean":0.05,"weightedMean":0.05,"std_dev":0,"confidence_interval_95":[0.05,0.05],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.05,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates negligible risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"curcumin_e100_efsa_2010_fda_gras","type":"regulatory","title":"Curcumin E100 CAS 458-37-7 CI Natural Yellow 3 (1E,6E)-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)Hepta-1,6-Diene-3,5-Dione; EFSA 2010 ADI 3 mg/kg/day NOAEL 250-400 mg/kg/day 2yr Rat EFSA Journal 2010;8(9):1679; FDA Exempt Color 21 CFR 73.600 GRAS; Turmeric Curcuma Longa Rhizome 2-5% Curcuminoids; Poor Oral Bioavailability ~1% Glucuronidation Sulfation First-Pass; Tetrahydrocurcumin Major Circulating Metabolite; Piperine Bioavailability Enhancer 20x; Nanoparticle Liposomal Delivery; In Vitro Genotoxicity Cytotoxic Threshold Not Direct Genotoxin Ames Negative; NF-kB COX-2 LOX Inhibition Anti-Inflammatory; 4000 Years Ayurvedic Indian Culinary Use; India 80-200mg/day Dietary Intake; Mustard Primary Food Colorant Application; Iron Chelation High Dose Supplement Risk; Uterotonic Effect High Dose Animal Studies Not Food Use","year":2010},{"id":"src_pubchem_tox_969516","type":"pubchem","title":"PubChem: Toxicity section (CID 969516)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/969516/JSON?heading=Toxicity"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"pubchem-computed-cid-969516","type":"database","title":"PubChem computed properties for CID 969516 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/969516"},{"id":"doc-2026-10-03-d975-ecotox-ascii-09-15-2026","type":"database","title":"EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026","url":"https://gaftp.epa.gov/ecotox/ecotox_ascii_09_15_2026.zip"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"ctx_pred_dtxsid8031077","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID8031077 (Curcumin (E100))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID8031077"},{"id":"pubchem-computed-structure-cid-969516","type":"database","title":"PubChem computed structure descriptors for CID 969516 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/969516"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — curcum","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":48,"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — curcum","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","human_pregnant","aquatic_life","human_teen","human_elderly","human_infant"]}