{"hq_id":"hq-c-org-000590","name":"Curcumin (E100)","context":"human_adult","timestamp":"2026-08-28T02:58:14.597Z","risk_level":"negligible","risk_profile":{"magnitude":{"mean":0.05,"weightedMean":0.05,"std_dev":0,"confidence_interval_95":[0.05,0.05],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.05,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"curcumin_e100_efsa_2010_fda_gras","type":"regulatory","title":"Curcumin E100 CAS 458-37-7 CI Natural Yellow 3 (1E,6E)-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)Hepta-1,6-Diene-3,5-Dione; EFSA 2010 ADI 3 mg/kg/day NOAEL 250-400 mg/kg/day 2yr Rat EFSA Journal 2010;8(9):1679; FDA Exempt Color 21 CFR 73.600 GRAS; Turmeric Curcuma Longa Rhizome 2-5% Curcuminoids; Poor Oral Bioavailability ~1% Glucuronidation Sulfation First-Pass; Tetrahydrocurcumin Major Circulating Metabolite; Piperine Bioavailability Enhancer 20x; Nanoparticle Liposomal Delivery; In Vitro Genotoxicity Cytotoxic Threshold Not Direct Genotoxin Ames Negative; NF-kB COX-2 LOX Inhibition Anti-Inflammatory; 4000 Years Ayurvedic Indian Culinary Use; India 80-200mg/day Dietary Intake; Mustard Primary Food Colorant Application; Iron Chelation High Dose Supplement Risk; Uterotonic Effect High Dose Animal Studies Not Food Use","year":2010}],"sources_scope":"record","warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — curcum","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":45,"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — curcum","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","human_pregnant","aquatic_life","human_teen","human_elderly","human_infant"]}