{"hq_id":"hq-c-org-000587","name":"Indigotine (Indigo Carmine; FD&C Blue No. 2; E132)","context":"human_adult","timestamp":"2026-08-28T02:41:50.995Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"indigotine_fdc_blue2_e132_efsa_2014","type":"regulatory","title":"Indigotine Indigo Carmine FD&C Blue No 2 E132 CAS 860-22-0 CI Food Blue 1 Acid Blue 74 Disodium Indigo-5,5'-Disulfonate; EFSA 2014 ADI 5 mg/kg/day No Genotoxicity Ames Negative EFSA Journal 2014;12(7):3768; FDA ADI 5 mg/kg/day FD&C Blue No 2; NOT Southampton 2007 Hyperactivity Study No EU Warning Label; Permitted US EU Canada Australia NZ Japan; Medical Use IV 200mg Urological Surgery Ureteral Identification Hypotension Bradycardia; GI Absorption <1% Disulfonate Groups; No Azo Bond No Azo Reductase Metabolism; Indigo Chromophore Bicyclic Oxindole UV-Vis 610nm Blue; Sulfonated Indigo Parent Indigofera Tinctoria Natural; Synthetic Production Sulfonation Indigo CAS 482-89-3","year":2014}],"sources_scope":"record","warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — indigo","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 17 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 17 positiv","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":40,"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — indigo","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 17 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 17 positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}