{"hq_id":"hq-c-org-000585","name":"Quinoline Yellow (E104)","context":"human_adult","timestamp":"2026-10-27T20:55:29.693Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000585","sha256":"735dab1aa90d6db0bcd20a7ba455788c8279a52b9cd8c15ccc3fa14d486edb30"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.3,"weightedMean":0.3,"std_dev":0,"confidence_interval_95":[0.3,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"quinolineyellow_e104_efsa_southampton_2009","type":"regulatory","title":"Quinoline Yellow E104 CAS 8004-92-0 Quinophthalone Dye NOT Azo; CI Acid Yellow 3 CI Food Yellow 13; Quinaldine + Phthalic Anhydride Quinophthalone Base Sulfonation; EFSA 2009 ADI 0.5 mg/kg/day NOAEL 50 mg/kg/day Rat Chronic Toxicity and Carcinogenicity Study; Southampton Mix B Only 7.5mg 8-9yr Children Hyperactivity Statistically Significant; EU Regulation 1333/2008 Mandatory Warning Label; Banned US FDA Canada Japan Australia NZ Norway; Parent Quinoline IARC Group 2B Vol 82 2002 Hepatocarcinogenic Animals; Contact Dermatitis Hairdressers Salon Workers Occupational; WWTP Poor Biodegradation Quinoline Derivatives","year":2009},{"id":"r60-2026-09-30-d969-efsa-2009-1329-quinoline-yellow","type":"regulatory","title":"Scientific Opinion on the re-evaluation of Quinoline Yellow (E 104) as a food additive","url":"https://doi.org/10.2903/j.efsa.2009.1329"},{"id":"pubchem-computed-cid-24671","type":"database","title":"PubChem computed properties for CID 24671 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/24671"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-computed-structure-cid-24671","type":"database","title":"PubChem computed structure descriptors for CID 24671 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/24671"}],"sources_scope":"record","derived_markers":[],"warnings":["single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":15},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}