{"hq_id":"hq-c-org-000584","name":"Carmoisine (Azorubine; E122)","context":"human_adult","timestamp":"2026-08-28T02:59:10.575Z","risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.27685,"weightedMean":0.27685,"std_dev":0.024931,"confidence_interval_95":[0.3,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.25,"weight":0.30176}]},"confidence":{"mean":0.648158,"weightedMean":0.648158,"std_dev":0.159561,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.707389,"weightedMean":0.707389,"std_dev":0.315133,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.838898,"weightedMean":0.838898,"std_dev":0.149589,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.841291,"weightedMean":0.841291,"std_dev":0.084767,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.833793,"disagreement_magnitude":0.353051,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. HQ_DIRECT classifies as higher risk (30th percentile), while EPA CTX / IARC concludes lower risk (25th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"carmoisine_e122_efsa_southampton_2009","type":"regulatory","title":"Carmoisine Azorubine E122 CAS 3567-69-9 Acid Red 14 CI Food Red 3 Monoazo Disulfonate; EFSA 2009 ADI 4 mg/kg/day NOAEL 600 mg/kg/day Rat 90-day Safety Factor 100; Southampton 2007 McCann Lancet Mix A 14.3mg Mix B 7.5mg Both Mixtures; Hyperactivity Children 3yr 8-9yr CGHAS Statistically Significant; EU Regulation 1333/2008 Mandatory Warning Label; Banned US FDA Canada Japan Australia NZ Norway; UK FSA 2009 Voluntary Reformulation Natural Colorants; Azo Bond Gut Reductase 4-Aminonaphthalene-1-Sulfonate Metabolites; Aspirin Cross-Reactivity Azo Intolerance; WWTP Limited Biodegradation Sludge Adsorption","year":2009}],"sources_scope":"record","warnings":["year_inferred:EPA CTX / IARC:2021","unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — carmoi","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 1 positive","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":41,"warnings":["year_inferred:EPA CTX / IARC:2021","unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — carmoi","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 1 positive"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}