{"hq_id":"hq-c-org-000583","name":"Ponceau 4R (Cochineal Red A; E124)","context":"human_adult","timestamp":"2026-10-27T18:50:02.128Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000583","sha256":"650fb4805db9de978ed869c320008e2b658c6380615cb0872bacdc49cd1758d6"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.3,"weightedMean":0.3,"std_dev":0,"confidence_interval_95":[0.3,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"ponceau4r_efsa_southampton_2009","type":"regulatory","title":"Ponceau 4R E124 CAS 2611-82-7 Cochineal Red A Acid Red 18 Trisulfonated Monoazo Dye; EFSA ADI 4 mg/kg/day 2009 Chronic Rat No Neoplasia NOAEL 1000 mg/kg/day Safety Factor 100; Southampton 2007 McCann Lancet Only Dye in BOTH Mix A 12.5mg Mix B 7.5mg; Hyperactivity 3yr 8-9yr Children Statistically Significant CGHAS; EU Regulation 1333/2008 Mandatory Warning Label Adverse Activity Attention; Banned US FDA Canada Japan Norway NZ; UK FSA 2009 Voluntary Removal Replaced Carmine Anthocyanins Beetroot Red; EFSA Azo Bond Gut Reductase Sulfonated Aromatic Amine; Aspirin Cross-Reactivity","year":2009},{"id":"r60-2026-09-28-d899-s3-b04-pmc-PMC13092938-efsa-2015-4073-ponceau-4r-exposure","type":"regulatory","title":"Refined exposure assessment for Ponceau 4R (E 124) - PMC","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13092938/"},{"id":"r60-2026-09-28-d899-s3-b03-cellar-02008R1333-20260818","type":"regulatory","title":"Consolidated TEXT: 32008R1333 — EN — 18.08.2026","url":"https://publications.europa.eu/resource/celex/02008R1333-20260818"},{"id":"r60-2026-09-28-d899-s3-b04-cellar-32012R0232","type":"regulatory","title":"L_2012078EN.01000101.xml","url":"https://publications.europa.eu/resource/celex/32012R0232"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"pubchem-computed-cid-17466","type":"database","title":"PubChem computed properties for CID 17466 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/17466"},{"id":"doc-2026-10-03-d975-ecotox-ascii-09-15-2026","type":"database","title":"EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026","url":"https://gaftp.epa.gov/ecotox/ecotox_ascii_09_15_2026.zip"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"ctx_pred_dtxsid9021213","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID9021213 (Ponceau 4R (Cochineal Red A; E124))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID9021213"},{"id":"pubchem-computed-structure-cid-17466","type":"database","title":"PubChem computed structure descriptors for CID 17466 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/17466"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — poncea","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":41,"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — poncea","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}