{"hq_id":"hq-c-org-000581","name":"Caramel color IV (E150d)","context":"human_adult","timestamp":"2026-08-28T02:50:36.279Z","risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.361842,"weightedMean":0.361842,"std_dev":0.149532,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"IARC","year":2020,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2020,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2020,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2020,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2020,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.00312,"disagreement_magnitude":0.335052,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (20th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"caramel4_regulatory_2020","type":"regulatory","title":"Caramel Color IV E150d Ammonia Sulfite Process Cola Beverages Soy Sauce Beer; 4-MEI 4-Methylimidazole Process Contaminant IARC Group 2B Vol 101 2013; NTP Mouse Lung Alveolar Bronchiolar Carcinoma B6C3F1 Strain; CA Prop 65 NSRL 29 μg/day Coca-Cola PepsiCo 2012 Reformulation; EFSA 2011 No Safety Concern at Current Exposure ADI 150 mg/kg/day E150d; EU EC 1333/2008 E150d 250 mg/kg 4-MEI Limit; Maillard Reaction Melanoidin Polymer; IARC Not Evaluated E150d Mixture; 4-MEI IARC 2B Species-Specific H-ras Mouse Lung","year":2020}],"sources_scope":"record","warnings":["unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 29 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 29 positiv","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":25,"warnings":["unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 29 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 29 positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}