{"hq_id":"hq-c-org-000577","name":"Sucralose","context":"human_adult","timestamp":"2026-08-28T01:28:19.038Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"sucralose_regulatory_2020","type":"regulatory","title":"Sucralose E955 Splenda 600x Sucrose Chlorinated Disaccharide; Hough Phadnis 1976 Tate Lyle Discovery Insecticide Research Taste; FDA 1998 21 CFR 172.831 EFSA ADI 15 mg/kg/day; Sucralose-6-Acetate S6A Genotoxicity Ames Comet 2023 Schiffman; Gut Microbiome Disruption Lactobacillus Bifidobacterium; High-Temperature Degradation Chlorinated Furans Baking >180C; WWTP Resistant Persistent Micropollutant Environmental Tracer; Photodegradation Chlorinated Products Surface Water; WHO 2023 NSS No Weight Benefit; EFSA Re-Evaluation Ongoing 2024; IARC Not Evaluated","year":2020}],"sources_scope":"record","warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — sucral","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 12 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 12 positiv","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":42,"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — sucral","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 12 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 12 positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}