{"hq_id":"hq-c-org-000575","name":"Diethyl ether","context":"human_adult","timestamp":"2026-10-27T18:00:14.356Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000575","sha256":"a1a6e419b4219087101fe8114efdfad955ee953132d6f081235be3b9bf1e6f6f"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.3,"weightedMean":0.3,"std_dev":0,"confidence_interval_95":[0.3,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"et2o_regulatory_2020","type":"regulatory","title":"Diethyl Ether Ethoxyethane Ether Historical General Anesthetic 1842 Crawford Long 1846 Ether Day Morton MGH; GABA-A Enhancement NMDA Inhibition Anesthetic Mechanism; Peroxide Formation Alpha-Carbon Autoxidation Explosive Distillation; DEA Table II List I Chemical Cocaine Coca Leaf Extraction Precursor; Resource-Limited Settings Sub-Saharan Africa Anesthesia; Engine Starting Fluid Volatile Substance Abuse Huffing Cardiac Arrest; EU CLP Flam Liq 1 H224 Flash Point -45C; Grignard Reaction LiAlH4 Solvent; ICH Q3C Class 3 PDE 50 mg/day; IARC Not Evaluated Not Carcinogen","year":2020},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_3283","type":"pubchem","title":"PubChem: Toxicity section (CID 3283)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/3283/JSON?heading=Toxicity"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"r60-2026-10-03-d923-niosh-npgd0277","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards - Ethyl ether","url":"https://www.cdc.gov/niosh/npg/npgd0277.html"},{"id":"r60-2026-09-25-d897-eu-cellar-02000L0039-20210520","type":"regulatory","title":"Consolidated TEXT: 32000L0039 — EN — 20.05.2021","url":"https://publications.europa.eu/resource/celex/02000L0039-20210520"},{"id":"doc-2026-10-03-d975-cfpub-epa-gov-ncea-pprtv-documents-ethylether-pdf","type":"assessment","title":"Provisional Peer Reviewed Toxicity Values for Ethyl ether (Diethyl ether) (CASRN 60-29-7)","url":"https://cfpub.epa.gov/ncea/pprtv/documents/EthylEther.pdf"},{"id":"doc-2026-10-03-d975-iris-epa-gov-static-pdfs-0423-summary-pdf","type":"assessment","title":"Ethyl ether; CASRN 60-29-7: IRIS Chemical Assessment Summary","url":"https://iris.epa.gov/static/pdfs/0423_summary.pdf"},{"id":"pubchem-computed-cid-3283","type":"database","title":"PubChem computed properties for CID 3283 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/3283"},{"id":"r60-2026-09-27-d820-osha-annotated-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-cameo-chemicals-cid-3283","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 3283; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/3283/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-3283","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 3283; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/3283/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-ilo-who-international-chemical-safety-ca-cid-3283","type":"database","title":"ILO-WHO International Chemical Safety Cards (ICSCs), as recorded by PubChem (Experimental Properties, CID 3283; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/3283/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid3021720","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID3021720 (Diethyl ether)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID3021720"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"pubchem-computed-structure-cid-3283","type":"database","title":"PubChem computed structure descriptors for CID 3283 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/3283"},{"id":"r60-2026-10-18-a5oj-eu-cellar-32008r1272-oj","type":"regulatory","title":"Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006: Annex VI, Part 3, Table 3.1 (Official Journal L 353, 31.12.2008)","year":2008,"url":"https://publications.europa.eu/resource/celex/32008R1272"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — diethy","unmapped_classification:EPA CTX / PPRTV (ORNL):inadequate for an assessment of carcinogenic poten","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":49,"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — diethy","unmapped_classification:EPA CTX / PPRTV (ORNL):inadequate for an assessment of carcinogenic poten","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}